Evidence map›Paper›PMID 39786528›Full record

ArticleJournal of assisted reproduction and genetics2025

Oocyte maturation defect in women undergoing IVF: contributing factors and effects on mature sibling oocyte outcomes.

Marga Esbert, Andrés Reig, Agustín Ballestros, Emre Seli

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07249411 (In Vitro Oocyte Maturation With Autologous Exosomes in Women With Low Ovarian Reserve), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07249411 nacompletednot on this map

In Vitro Oocyte Maturation With Autologous Exosomes in Women With Low Ovarian Reserve: Preliminary Phase of a Prospective Randomized Clinical Study

TypeinterventionalSponsorBiotech Fertility C.A.Ran2023 to 2025Enrolled32ConditionsDiminished Ovarian ReserveArmsMI oocytes were cultured in conventional IVM medium supplemented with 10 µg of autologous exosomes obtained using the ExoSMarT® exosome filtration system
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marga EsbertIVIRMA Global Research Alliance, IVI Barcelona, 45 Mallorca, 08017, Barcelona, Spain. marga.esbert@ivirma.com.ORCID http://orcid.org/0000-0002-0002-2272
Andrés ReigIVIRMA Global Research Alliance, RMA New Jersey, 140 Allen, Basking Ridge, NJ, 07920, USA.
Agustín BallestrosIVIRMA Global Research Alliance, IVI Barcelona, 45 Mallorca, 08017, Barcelona, Spain.
Emre SeliIVIRMA Global Research Alliance, RMA New Jersey, 140 Allen, Basking Ridge, NJ, 07920, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to identify demographic and clinical factors associated with low maturation rates and to investigate if the rate of immature oocytes impacts the outcomes of mature sibling oocytes.

methodsWomen undergoing their first IVF-ICSI cycle between 2018 and 2022 at a fertility clinic were included. Cycles were classified into five groups according to the proportion of Metaphase II stage oocytes (MII): Null (0% MII, n = 46), Poor (1-25% MII, n = 44), Low (26-50% MII, n = 453), Acceptable (51-75% MII, n = 1641), and Optimal (76-100% MII, n = 2642). Demographic characteristics and clinical outcomes were compared between the five groups. In patients with a Null/Poor maturation rate, subsequent cycle outcomes were also evaluated.

resultsA total of 4826 cycles were included in the study; 69,909 oocytes were recovered, and 53,065 were MIIs (75.9%). The Null group was older, had lower levels of anti-Müllerian hormone (AMH), needed more gonadotropins and days of stimulation, had higher follicle stimulating hormone (FSH) levels on day 3, and had less follicles > 15 mm on the day of trigger. When the outcomes of mature oocytes were compared, fertilization, usable blastocyst, aneuploidy, and life birth rates were comparable among groups. A binary logistic regression model using number of oocytes, paternal age, and trigger type with live birth rate endpoint found no differences between the categories and the base line Poor category. When patients whose maturation rate was Null/Poor, 42 (47.0%) carried out a second cycle; the maturation rate increased (56.9 ± 31.5 vs. 11.6 ± 11.2%, P < 0.0001).

conclusionOur data suggest that poor responders are more likely to have low rates of oocyte maturation. The proportion of immature oocytes does not impact the outcomes of mature sibling oocytes. In patients with Null/Poor maturation in their first cycle, the subsequent cycle is often associated with improved maturation rates.

Indexed as

Fertilization in VitroIn Vitro Oocyte Maturation TechniquesOocytesOogenesisAdultAnti-Mullerian HormoneFemaleFollicle Stimulating HormoneHumansOocyte RetrievalOvarian FollicleOvulation InductionPregnancyPregnancy RateSiblingsSperm Injections, IntracytoplasmicAnti-Mullerian HormoneFollicle Stimulating HormoneFertilization rateICSINuclear maturityNull maturationOocyte competenceOocyte maturation

Identifiers

PMID39786528
PMCPMC11950596

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Registered trials

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