Evidence map›Paper›PMID 39785844›Full record

ArticleMolecular biology of the cell2025

Large, recursive membrane platforms are associated to Trop-1, Trop-2, and protein kinase signaling for cell growth.

Marco Trerotola, Valeria Relli, Romina Tripaldi, Pasquale Simeone, Emanuela Guerra, Andrea Sacchetti, Martina Ceci, Ludovica Pantalone, Paolo Ciufici, Antonino Moschella and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marco TrerotolaLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Valeria RelliLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Romina TripaldiLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Pasquale SimeoneLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Emanuela GuerraLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Andrea SacchettiDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Martina Ceci
Ludovica PantaloneLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Paolo CiuficiLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
Antonino MoschellaUnit of Medical Genetics, Department of Biomedical Sciences (BIOMORF), University of Messina, Messina, Italy.
Valeria R CaiolfaMicroscopy and Dynamic Imaging Unit, Centro National de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Moreno ZamaiMicroscopy and Dynamic Imaging Unit, Centro National de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Saverio AlbertiLaboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.ORCID 0000-0002-4647-6042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transmembrane glycoproteins Trop-1/EpCAM and Trop-2 independently trigger Ca

Indexed as

Antigens, NeoplasmCell Adhesion MoleculesAnimalsCalciumCalcium SignalingCell MembraneCell ProliferationHumansPhosphorylationProtein Kinase C-alphaProtein KinasesSignal TransductionTropomyosinAntigens, NeoplasmCalciumCell Adhesion MoleculesProtein Kinase C-alphaProtein KinasesTACSTD2 protein, humanTropomyosin

Identifiers

PMID39785844
PMCPMC11974968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.