Evidence map›Paper›PMID 39785820›Full record

ArticleMolecular biology of the cell2025

Cul3 substrate adaptor SPOP targets Nup153 for degradation.

Joseph Y Ong, Mai Abdusamad, Ivan Ramirez, Ankur Gholkar, Xiaoxuan Zhang, Thomas V Gimeno, Jorge Z Torres

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Joseph Y OngDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Mai AbdusamadDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Ivan RamirezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Ankur GholkarDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Xiaoxuan ZhangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Thomas V GimenoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Jorge Z TorresDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-2158-889X

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Investigating the Cell Division MachineryR35GM139539 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 2021 to 2025
$2.2M
Novel Regulatory Factors of the Spindle Assembly CheckpointR01GM117475 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 2016 to 2020
$1.7M
Defining the role of DUSP12 in the regulation of cell division and apoptosis.F31GM154466 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABDUSAMAD, MAI · 2024 to 2025
$66k
NIGMS NIH HHS F31 GM154466NIGMS NIH HHS R01 GM117475NIGMS NIH HHS R35 GM139539NIGMS NIH HHS T32 GM007185NIGMS NIH HHS T32 GM145388
6 · The paper itself

Abstract

SPOP is a Cul3 substrate adaptor responsible for the degradation of many proteins related to cell growth and proliferation. Because mutation or misregulation of SPOP drives cancer progression, understanding the suite of SPOP substrates is important to understanding the regulation of cell proliferation. Here, we identify Nup153, a component of the nuclear basket of the nuclear pore complex, as a novel substrate of SPOP. SPOP and Nup153 bind to each other and colocalize at the nuclear envelope and some nuclear foci in cells. The binding interaction between SPOP and Nup153 is complex and multivalent. Nup153 is ubiquitylated and degraded upon expression of SPOP

Indexed as

Cullin ProteinsNuclear Pore Complex ProteinsNuclear ProteinsRepressor ProteinsCell Cycle ProteinsHeLa CellsHumansNuclear EnvelopeNuclear PoreProtein BindingProteolysisUbiquitinationCell Cycle ProteinsCUL3 protein, humanCullin ProteinsNuclear Pore Complex ProteinsNuclear ProteinsNUP153 protein, humanRepressor ProteinsSPOP protein, human

Identifiers

PMID39785820
PMCPMC11974958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.