ArticlePsychological medicine2024
Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology.
Article in Psychological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Neural mechanisms of negative emotionality and cognitive control: The role of frontal midline theta.Cognitive, affective & behavioral neuroscience · 2026Article
- Childhood paternal abuse and low paternal affection predict adult panic symptoms 18 years later via actigraphy-indexed sleep disruptions.Psychological medicine · 2026Article
- Interpersonal adversity and health across the life course.Current opinion in psychology · 2026Review
- Letter to the editor: Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology.Psychological medicine · 2025Article
- Association between the psychological frailty index and stroke: a cohort study from CHARLS.Scientific reports · 2025Article
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Authors and funding
5 authors.
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Abstract
backgroundChildhood adversity has been associated with increased peripheral inflammation in adulthood. However, not all individuals who experience early adversity develop these inflammatory outcomes. Separately, there is also a link between various internalizing emotional distress conditions (e.g. depression, anxiety, and fear) and inflammation in adulthood. It is possible the combination of adult emotional distress and past childhood adversity may be uniquely important for explaining psychopathology-related immune dysfunction at midlife.
methodsUsing data from the Midlife in the United States (MIDUS) study (
resultsWe observed that childhood adversity only predicted adult inflammation when participants also reported adult internalizing emotional distress. Furthermore, this moderation effect was specific to the transdiagnostic factor of emotional distress rather than the disorder-specific features.
conclusionsWe discuss the possibility that adult internalizing symptoms and trait neuroticism together may signal the presence of temporally stable vulnerabilities that amplify the impact of childhood adversity on midlife immune alterations. The study highlights the importance of identifying emotional distress in individuals who have experienced childhood adversity to address long-term immune outcomes and enhance overall health.
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