Evidence map›Paper›PMID 39781579›Full record

GuidelineAnaesthesia2025

Association of Anaesthetists guidelines: the use of blood components and their alternatives.

Akshay Shah, Andrew A Klein, Seema Agarwal, Andrew Lindley, Aamer Ahmed, Kerry Dowling, Emma Jackson, Sumit Das, Divya Raviraj, Rachel Collis and 3 more

Erratum issuedAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Akshay ShahNuffield Department of Clinical Neurosciences and NIHR Blood and Transplant Research Unit in Data Driven Transfusion Practice, University of Oxford, Oxford, UK.ORCID 0000-0002-1869-2231
Andrew A KleinDepartment of Anaesthesia and Intensive Care, Royal Papworth Hospital, Cambridge, UK and Chair, Working Party, Association of Anaesthetists.ORCID 0000-0001-9913-6570
Seema AgarwalDepartment of Anaesthesia, Manchester University NHS Foundation Trust, Manchester, UK and the Association of Anaesthetists.ORCID 0000-0002-9991-507X
Andrew LindleyDepartment of Anaesthesia, Leeds Teaching Hospitals NHS Trust and Royal College of Anaesthetists.
Aamer AhmedDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Kerry DowlingTransfusion Laboratories, Southampton University Hospitals NHS Foundation Trust.
Emma JacksonDepartment of Cardiothoracic Anaesthesia, Critical Care, Anaesthesia and ECMO, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK and Intensive Care Society UK.
Sumit DasNuffield Department of Anaesthesia, Oxford University Hospitals NHS Foundation Trust, Oxford, UK and the Association of Paediatric Anaesthetists of Great Britain and Ireland and the Royal College of Anaesthetists.
Divya RavirajResident Doctors Committee, the Association of Anaesthetists.
Rachel CollisDepartment of Anaesthesia, University Hospital of Wales, Cardiff, UK and the Obstetric Anaesthetists Association.ORCID 0000-0003-2107-7990
Anna SharrockDepartment of Vascular Surgery, Frimley Health NHS Foundation Trust, Frimley, UK.
Simon J StanworthNIHR Blood and Transplant Research Unit in Data Driven Transfusion Practice, Radcliffe Department of Medicine, University of Oxford and on behalf of the British Society of Haematology and NHS Blood and Transplant.ORCID 0000-0002-7414-4950
Paul MoorDepartment of Anaesthesia, Derriford Hospital, Plymouth, UK and the Defence Anaesthesia Representative.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri-operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and improved haemovigilance, have become apparent over the past decade. The aim of these updated guidelines is to provide an evidence-based set of recommendations so that anaesthetists and peri-operative physicians might provide high-quality care.

methodsAn expert multidisciplinary, multi-society working party conducted targeted literature reviews, followed by a three-round Delphi process to produce these guidelines.

resultsWe agreed on 12 key recommendations. Overall, these highlight the importance of organisational factors for safe transfusion and timely provision of blood components; the need for protocols that are targeted to different clinical contexts of major bleeding; and strategies to avoid the need for transfusion, minimise bleeding and manage anticoagulant therapy.

conclusionsAll anaesthetists involved in the care of patients at risk of major bleeding and peri-operative transfusion should be aware of the treatment options and approaches that are available to them. These contemporary guidelines aim to provide recommendations across a range of clinical situations.

Indexed as

AnesthesiologyAnesthetistsBlood Component TransfusionBlood TransfusionDelphi TechniqueHemorrhageHumansPerioperative Carebleedingmajor haemorrhageperi‐operativetranexamic acidtransfusion

Identifiers

PMID39781579
PMCPMC11885198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.