Evidence map›Paper›PMID 39781571›Full record

GuidelineAnaesthesia2025

Elective peri-operative management of adults taking glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic peptide agonists and sodium-glucose cotransporter-2 inhibitors: a multidisciplinary consensus statement: A consensus statement from the Association of Anaesthetists, Association of British Clinical Diabetologists, British Obesity and Metabolic Surgery Society, Centre for Perioperative Care, Joint British Diabetes Societies for Inpatient Care, Royal College of Anaesthetists, Society for Obesity and Bariatric Anaesthesia and UK Clinical Pharmacy Association.

Kariem El-Boghdadly, Jugdeep Dhesi, Philippa Fabb, Nicholas Levy, Dileep N Lobo, Andrew McKechnie, Omar Mustafa, Philip Newland-Jones, Anil Patel, Dimitri J Pournaras and 2 more

Registry-linked trialAbstract readPractice GuidelineConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07100691 (Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss), which is not on this map. Cited by 49 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07100691 phase4not yet recruitingnot on this map

Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss: A Randomised Controlled Trial With Ultrasound Assessment

TypeinterventionalSponsorMater Misericordiae University HospitalRan2025 to 2026Enrolled80ConditionsPulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)ArmsMetoclopramide
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. [Hospital diabetes management (Update 2026)].Wiener klinische Wochenschrift · 2026
    Guideline
  4. Guideline
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Preoperative fasting guidelines: A narrative review.European journal of anaesthesiology and intensive care · 2026
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kariem El-BoghdadlyDepartment of Anaesthesia and Perioperative Care, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-9912-717X
Jugdeep DhesiKing's College London, London, UK.ORCID 0000-0003-0815-0233
Philippa FabbDepartment of Anaesthesia, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Nicholas LevyDepartment of Anaesthesia and Perioperative Medicine, West Suffolk NHS Foundation Trust, Suffolk, UK.ORCID 0000-0002-2225-1535
Dileep N LoboDivision of Translational Medical Sciences, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK.ORCID 0000-0003-1187-5796
Andrew McKechnieDepartment of Anaesthesia, Lewisham and Greenwich NHS Trust, London, UK.
Omar MustafaDepartment of Diabetes, King's College Hospital, London, UK.
Philip Newland-JonesDepartment of Diabetes and Endocrinology, University of Southampton, Southampton, UK.ORCID 0000-0001-6056-0008
Anil PatelDepartment of Anaesthesia, University College London, London, UK.
Dimitri J PournarasBristol Weight Management and Bariatric Service, North Bristol NHS Trust, Bristol, UK.ORCID 0000-0001-8798-920X
Ken ClarePatient Representative.
Ketan DhatariyaDepartment of Medicine, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.ORCID 0000-0003-3619-9579

Funding

Royal College of Surgeons of England
6 · The paper itself

Abstract

introductionGlucagon-like peptide-1 receptor agonists, dual glucose-dependent insulinotropic peptide receptor agonists and sodium-glucose cotransporter-2 inhibitors are used increasingly in patients receiving peri-operative care. These drugs may be associated with risks of peri-operative pulmonary aspiration or euglycaemic ketoacidosis. We produced a consensus statement for the peri-operative management of adults taking these drugs.

methodsThis multidisciplinary consensus statement included surgeons, anaesthetists, physicians, pharmacists and people with lived experience relevant to these guidelines. Following the directed literature review, a three-round modified Delphi process was conducted to generate and ratify recommendations.

resultsPatients taking glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic peptide receptor agonists should: continue these drugs before surgery; have full risk assessment and stratification; and receive peri-operative techniques that may mitigate risk of pulmonary aspiration before, during and after sedation or general anaesthesia. Patients taking sodium-glucose cotransporter-2 inhibitors should omit them the day before and the day of a procedure. All patients should have risks and mitigation strategies discussed with a shared decision-making approach. DISCUSSION: Until more evidence becomes available, this pragmatic, multidisciplinary consensus statement aims to support shared decision-making and improve safety for patients taking glucagon-like peptide-1 receptor agonists, dual glucose-dependent insulinotropic peptide receptor agonists and sodium-glucose cotransporter-2 inhibitors during the peri-operative period.

Indexed as

Elective Surgical ProceduresGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsPerioperative CareSodium-Glucose Transporter 2 InhibitorsAdultHumansGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsSodium-Glucose Transporter 2 Inhibitorsanaesthesiaaspirationdiabetes mellitusgastric emptyingGLP‐1RA based treatmentSGLT2 inhibitors

Identifiers

PMID39781571
PMCPMC11885194

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.