ArticleJournal of exercise rehabilitation2024
The effects of weight- and non-weight-bearing exercise on corticospinal axon sprouting, regeneration-related proteins and functional recovery after spinal cord contusion.
Article in Journal of exercise rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Combined effects of treadmill exercise and naringenin treatment on neuronal survival and corticospinal tract fibers sprouting after spinal cord injury.Journal of exercise rehabilitation · 2026Article
- Exercise training promotes nerve cell repair and regeneration after spinal cord injury.Neural regeneration research · 2026Article
- Comparative study of treadmill and swimming exercises on spinal regeneration and reactive astrocytes in the brain after spinal cord injury.Journal of exercise rehabilitation · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the effects of weight- and non-weight-bearing exercises on the Basso-Beattie-Bresnahan (BBB) locomotor rating scale, corticospinal axon regrowth and regeneration-related proteins following spinal cord injury (SCI). Twenty-four male Sprague-Dawley rats were randomly divided into four groups: control group (n=6), SCI+sedentary group (SED, n=6), SCI+treadmill exercise group (TREAD, n=6), and SCI+swimming exercise group (SWIM, n=6). All rats in the SCI group were given the rest for 2 weeks after SCI, and then they were allowed to engage in low-intensity exercise for 6 weeks on treadmill device. Motor function (BBB score) was improved more in the SWIM group compared to the SED group at 3 and 6 weeks after SCI. The SWIM group also showed higher levels of axonal outgrowth in corticospinal tract and increased expression of phosphorylated extracellular signal-regulated kinase, a marker of axonal regeneration in the dorsal horn of the caudal region, compared to the TREAD group. Additionally, the SWIM group significantly upregulated the expression of regeneration-related proteins. Our findings suggest that non-weight-bearing exercise may be one of several rehabilitation methods for improving locomotor function and corticospinal axon regeneration after SCI.
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