ArticleClinical kidney journal2025
Urinary RANTES and MCP-1 as noninvasive biomarkers for differential diagnosis and prediction of treatment response in acute interstitial nephritis.
Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- From immune dysregulation to renal injury: mechanistic insights and translational opportunities in immune-mediated nephropathies.Frontiers in cell and developmental biology · 2026Review
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7 authors.
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Abstract
Background: Although kidney biopsy is definitive for the diagnosis of acute interstitial nephritis (AIN) and acute tubular necrosis (ATN), its invasiveness limits its use. We aimed to identify urine biomarkers for differentiating AIN and ATN and to predict the response of patients with AIN to steroid treatment. Methods: In this prospective cohort study, biopsy-proven ATN ( Results: The urinary RANTES/creatinine ratio and the percentages of intrarenal CD45-, CD3-, CD20- and Ki-67-positive cells were significantly higher in the AIN group than in the ATN group ( Conclusions: The potential of the urinary RANTES/creatinine ratio as a noninvasive biomarker for differentiating AIN from ATN is highlighted. Urinary MCP-1/creatinine levels and the proportion of total intrarenal leukocytes and proliferating tubular cells may serve as indicators for predicting the response of patients with AIN to steroid treatment.
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