Evidence map›Paper›PMID 39781465›Full record

ArticleInternational journal of biological sciences2025

Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway.

Thi Tuyet Mai Pham, Mikyung Kim, Thuy Quynh Nhu Nguyen, Jae-Hyung Park, Jee In Kim, Ji Hae Seo, Jin Young Kim, Eunyoung Ha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thi Tuyet Mai PhamDepartment of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Mikyung KimDepartment of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Thuy Quynh Nhu NguyenDepartment of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Jae-Hyung ParkDepartment of Physiology, School of Medicine, Keimyung University, Republic of Korea.
Jee In KimDepartment of Molecular Medicine, School of Medicine, Keimyung University, Republic of Korea.
Ji Hae SeoDepartment of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Jin Young KimDivision of Haematology and Oncology, Department of Internal Medicine, School of Medicine, Keimyung University, Republic of Korea.
Eunyoung HaDepartment of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) is considered as a "metabolic disease" due to various perturbations in metabolic pathways that could drive cancer development. Glycine decarboxylase (GLDC) is a mitochondrial enzyme that takes part in the oxidation of glycine to support nucleotide biosynthesis via transfer of one-carbon units. Herein, we aimed to investigate the potential role of GLDC in RCC development. We found that GLDC depletion diminished nucleotide synthesis and promoted reactive oxygen species (ROS) generation to repress RCC progression, which was reversed by repletion of deoxynucleosides. Additionally,

Indexed as

Carcinoma, Renal CellGlycine Dehydrogenase (Decarboxylating)Kidney NeoplasmsAnimalsCell Line, TumorCell ProliferationHumansInterferon-Stimulated Gene Factor 3, gamma SubunitMiceMice, NudeReactive Oxygen SpeciesSignal TransductionGlycine Dehydrogenase (Decarboxylating)Interferon-Stimulated Gene Factor 3, gamma SubunitIRF9 protein, humanReactive Oxygen SpeciesGLDCinterferon stimulated gene factor 3nucleotide synthesisoxidative stressrenal cell carcinoma

Identifiers

PMID39781465
PMCPMC11705630

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.