Evidence map›Paper›PMID 39781370›Full record

ArticlePolymer chemistry2024

Insights into conformational ensembles of compositionally identical disordered peptidomimetics.

Erin C Day, Keila C Cunha, Roy J Zhao, Audra J DeStefano, James N Dodds, Melissa A Yu, Jaina R Bemis, Songi Han, Erin S Baker, Joan-Emma Shea and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erin C DayDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-9278-9560
Keila C CunhaDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Roy J ZhaoDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Audra J DeStefanoDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
James N DoddsDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Melissa A YuDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Jaina R BemisDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Songi HanDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Erin S BakerDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-5246-2213
Joan-Emma SheaDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Rebecca B BerlowDepartment of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0003-1934-0139
Abigail S KnightDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0003-1524-473X

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu · 2017 to 2026
$21.2M
Understanding the role of lipids in structure and function of membrane proteinsRM1GM145416 · NIGMS · TEXAS A&M UNIVERSITY · PI Erin S Baker, Arthur D Laganowsky · 2022 to 2026
$7.4M
Water as essential building blocks to direct protein structure and functionR35GM136411 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Songi Han · 2020 to 2026
$2.4M
NCI NIH HHS P30 CA016086NIEHS NIH HHS P42 ES027704NIGMS NIH HHS R35 GM136411NIGMS NIH HHS RM1 GM145416
6 · The paper itself

Abstract

While the conformational ensembles of disordered peptides and peptidomimetics are complex and challenging to characterize, they are a critical component in the paradigm connecting macromolecule sequence, structure, and function. In molecules that do not adopt a single predominant conformation, the conformational ensemble contains rich structural information that, if accessible, can provide a fundamental understanding related to desirable functions such as cell penetration of a therapeutic or the generation of tunable enzyme-mimetic architecture. To address the fundamental challenge of describing broad conformational ensembles, we developed a model system of peptidomimetics comprised of polar glycine and hydrophobic

Identifiers

PMID39781370
PMCPMC11709448

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.