Evidence map›Paper›PMID 39781112›Full record

ArticleACS applied nano materials2022

Increasing the Efficacy of Gold Nanorod Uptake in Stem Cell-Derived Therapeutic Cells: Implications for Stem Cell Labeling and Optical Coherence Tomography Imaging.

Grant W Marquart, Jonathan Stoddard, Karen Kinnison, Felicia Zhou, Richard Hugo, Renee Ryals, Scott Shubert, Trevor J McGill, Marilyn R Mackiewicz

Abstract read
In one paragraph

Article in ACS applied nano materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grant W MarquartDepartment of Chemistry, Portland State University, Portland, Oregon 97207, United States.
Jonathan StoddardCasey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Karen KinnisonDepartment of Chemistry, Portland State University, Portland, Oregon 97207, United States.
Felicia ZhouDepartment of Chemistry, Portland State University, Portland, Oregon 97207, United States.
Richard HugoDepartment of Chemistry, Portland State University, Portland, Oregon 97207, United States.
Renee RyalsCasey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Scott ShubertCasey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Trevor J McGillCasey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Marilyn R MackiewiczDepartment of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0002-5669-8714

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
EXITO: Enhancing Cross-disciplinary Infrastructure and Training at OregonUL1GM118964 · NIGMS · PORTLAND STATE UNIVERSITY · PI KELLER, THOMAS E · 2015 to 2023
$18.0M
EXITO: Enhancing Cross-disciplinary Infrastructure and Training at OregonRL5GM118963 · NIGMS · PORTLAND STATE UNIVERSITY · PI KELLER, THOMAS E · 2015 to 2023
$11.9M
EXITO: Enhancing Cross-disciplinary Infrastructure and Training at OregonTL4GM118965 · NIGMS · PORTLAND STATE UNIVERSITY · PI KELLER, THOMAS E · 2015 to 2022
$10.1M
NIGMS NIH HHS RL5 GM118963NIGMS NIH HHS TL4 GM118965NIGMS NIH HHS UL1 GM118964NIH HHS P51 OD011092
6 · The paper itself

Abstract

The advancement of safe nanomaterials for use as optical coherence tomography (OCT) imaging and stem cell-labeling agents to longitudinally visually track therapeutic derived retinal stem cells to study their migration, survival rate, and efficacy is challenged by instability, intracellular aggregation, low uptake, and cytotoxicity. Here, we describe a series of hybrid lipid-coated gold nanorods (AuNRs) that could solve these issues. These nanomaterials were made via a layer-by-layer assembly approach, and their stability in biological media, mechanism, efficiency of uptake, and toxicity were compared with a commercially available set of AuNRs with a 5 nm mesoporous silica (mSiO

Indexed as

cell-penetrating peptidescell uptake studieslipid-coated gold nanorodsoptical coherence tomography imagingstem cellstoxicity

Identifiers

PMID39781112
PMCPMC11706712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.