Evidence map›Paper›PMID 39781054›Full record

ArticleBiomedical engineering letters2025

Expansion of stereotactic work envelope using transformation matrices and geometric algebra for neurosurgery.

Basel Sharaf, Seth Lewis, David Choung, Abhinav Goyal, Kristen M Scheitler, Lydia S Hong, Charles D Blaha, Barbara Hanna, Kyungwon Chang, Jason Yuen and 6 more

Abstract read
In one paragraph

Article in Biomedical engineering letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Basel Sharaf *Division of Plastic Surgery, Mayo Clinic, Rochester, MN USA.
Seth Lewis *NaviNetics, Inc, Rochester, MN USA.
David ChoungNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Abhinav GoyalNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Kristen M ScheitlerNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Lydia S HongDepartment of Neurosurgery, Mayo Clinic, Rochester, MN USA.
Charles D BlahaNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Barbara HannaNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Kyungwon ChangDepartment of Neurosurgery, Samsung Medical Center, Seoul, South Korea.
Jason YuenNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Yoonbae OhNaviNetics, Inc, Rochester, MN USA.
Hojin ShinNeural Engineering Laboratories, Mayo Clinic, Rochester, MN USA.
Sanjeet GrewalDepartment of Neurological Surgery, Mayo Clinic, Jacksonville, FL USA.
Jin Woo ChangDepartment of Neurosurgery, Korea University Anam Hospital, Seoul, South Korea.
Kai MillerDepartment of Neurosurgery, Mayo Clinic, Rochester, MN USA.
Kendall H LeeNaviNetics, Inc, Rochester, MN USA.

Funding

An Integrated Neurochemical/Electrophysiological Recording and Neuromodulation System for Basic and Clinical ResearchR42NS125895 · NINDS · WINCS INTERNATIONAL, LLC · PI Kevin Elliott Bennet, Kendall Lee · 2022 to 2026
$2.3M
Development of an innovative in vivo voltammetric technique for measurements of tonic serotonin concentrations in the mammalian brain.R01NS129549 · NINDS · MAYO CLINIC ROCHESTER · PI Kendall H. Lee, Yoonbae Oh · 2023 to 2026
$2.3M
Development of advanced voltammetric method for basal neurotransmitter level measurementR01NS112176 · NINDS · MAYO CLINIC ROCHESTER · PI LEE, KENDALL H., OH, YOONBAE · 2019 to 2022
$1.4M
NINDS NIH HHS R01 NS112176NINDS NIH HHS R01 NS129549NINDS NIH HHS R42 NS125895
6 · The paper itself

Abstract

Stereotactic systems have traditionally used Cartesian coordinate combined with linear algebraic mathematical models to navigate the brain. Previously, the development of a novel stereotactic system allowed for improved patient comfort, reduced size, and carried through a simplified interface for surgeons. The system was designed with a work envelope and trajectory range optimized for deep brain stimulation applications only. However, it could be applied in multiple realms of neurosurgery by spanning the entire brain. To this end, a system of translational and rotational adapters was developed to allow total brain navigation capabilities. Adapters were designed to fit onto a Skull Anchor Key of a stereotactic frame system to allow for rotation and translation of the work envelope. Mathematical formulas for the rotations and translations associated with each adapter were developed. Mechanical and image-guided accuracies were examined using a ground truth imaging phantom. The system's clinical workflow and its ability to reliably and accurately be used in a surgical scenario were investigated using a cadaver head and computed tomography guidance. Eight adapters designed and 3D-printed allowed the work envelope to be expanded to the entire head. The mechanical error was 1.75 ± 0.09 mm (

Indexed as

Deep brain stimulationGeometric algebraNeurosurgical navigationStereotactic frame

Identifiers

PMID39781054
PMCPMC11704102

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.