ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community-dwelling cohort.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comprehensive social determinants of health and brain health in midlife.The journal of prevention of Alzheimer's disease · 2026Article
- Associations of Place-based Social Determinants of Health with Biomarkers of Alzheimer's Disease and Related Dementias.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Perceived neighborhood environments and cardiovascular disease in older adults: the moderating role of cognitive activity.Innovation in aging · 2025Article
- Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community-dwelling cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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13 authors.
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Abstract
introductionNeighborhood disadvantage may be an important determinant of cardiometabolic health and cognitive aging. However, less is known about relationships among individuals with mild cognitive impairment (MCI).
methodsThe objective of this study is to investigate the relationship between neighborhood disadvantage measured by national Area Deprivation Index (ADI) rank with measures of cardiometabolic health and cognition among Wake Forest (WF) Alzheimer's Disease Research Center (ADRC) participants, with and without MCI.
resultsADI was positively associated with blood pressure and cardiometabolic index (CMI), and negatively associated with global and Preclinical Alzheimer's Cognitive Composite (PACC5) scores, in cognitively unimpaired (CU) individuals. ADI was only positively associated with hemoglobin A1c (HbA1c) in MCI. DISCUSSION: Neighborhood disadvantage is associated more strongly with measures of cardiometabolic health and cognition among CU individuals rather than MCI. These findings demonstrate a need for structural solutions to address social determinants of health in an attempt to reduce cardiometabolic and cognitive risks.
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