Evidence map›Paper›PMID 39779967›Full record

ArticleActa pharmacologica Sinica2025

Compound 38, a novel potent and selective antagonist of adenosine A

Hui Zhang, Wei-Xiang Ma, Qiong Xie, Li-Fang Bu, Ling-Xi Kong, Ping-Chuan Yuan, Rong-Hui Zhou, Yong-Hui Wang, Lei Wu, Chen-Yu Zhu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hui Zhang *Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wannan Medical College, Wuhu, 241002, China.
Wei-Xiang Ma *Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China.
Qiong Xie *Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Li-Fang BuDepartment of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China.
Ling-Xi KongDepartment of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China.
Ping-Chuan YuanAnhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wannan Medical College, Wuhu, 241002, China.
Rong-Hui ZhouDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Yong-Hui WangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Lei WuDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Chen-Yu ZhuDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Zhi-Lin WangDepartment of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China.
Jun HanAnhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wannan Medical College, Wuhu, 241002, China. hanjun@wnmc.edu.cn.
Zhi-Li HuangDepartment of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China. huangzl@fudan.edu.cn.
Yi-Qun WangDepartment of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Joint International Research Laboratory of Sleep, Fudan University, Shanghai, 200032, China. yiqunwang@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine A

Indexed as

Adenosine A2 Receptor AntagonistsArousalReceptor, Adenosine A2AAnimalsDose-Response Relationship, DrugElectroencephalographyMaleMiceMice, Inbred C57BLMice, KnockoutSleepSleep DeprivationWakefulnessAdenosine A2 Receptor AntagonistsReceptor, Adenosine A2AA2AR antagonistA2AR KO micearousal-promoting effectCompound 38sleep deprivationsleep–wake states

Identifiers

PMID39779967
PMCPMC12032279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.