Evidence map›Paper›PMID 39779902›Full record

ArticleNature chemical biology2026

Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI.

Hsuan-Ai Chen, Takumi Okuda, Ann-Kathrin Lenz, Carolin P M Scheitl, Hermann Schindelin, Claudia Höbartner

Abstract read
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. ChemBioParis 2025: Approaching Biology Through Chemistry in the City of Light.Chembiochem : a European journal of chemical biology · 2026
    Article
  3. Review
  4. Article
  5. Alkyltransferase Ribozyme for Site-Specific NAngewandte Chemie (International ed. in English) · 2026
    Article
  6. Dual Stabilization ofJACS Au · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Assessment of nucleic acid structure prediction in CASP16.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hsuan-Ai Chen *Institute of Organic Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-0586-0742
Takumi Okuda *Institute of Organic Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2136-6525
Ann-Kathrin LenzInstitute of Organic Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0009-0006-2700-2083
Carolin P M ScheitlInstitute of Organic Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0009-0000-7822-2066
Hermann SchindelinRudolf Virchow Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany. hermann.schindelin@uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-2067-3187
Claudia HöbartnerInstitute of Organic Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany. claudia.hoebartner@uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-4548-2299

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 463143961
6 · The paper itself

Abstract

Ribozymes that catalyze site-specific RNA modification have recently gained increasing interest for their ability to mimic methyltransferase enzymes and for their application to install molecular tags. Recently, we reported SAMURI as a site-specific alkyltransferase ribozyme using S-adenosylmethionine (SAM) or a stabilized analog to transfer a methyl or propargyl group to N

Indexed as

RNA, CatalyticS-AdenosylmethionineBiocatalysisCatalysisCrystallography, X-RayModels, MolecularNucleic Acid ConformationRiboswitchSubstrate SpecificityRiboswitchRNA, CatalyticS-Adenosylmethionine

Identifiers

PMID39779902
PMCPMC13226088

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.