ArticleNature microbiology2025
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection.
Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The removal of iron and phosphate from culture medium by Rhodococcus ruber SiAl.Folia microbiologica · 2026Article
- Arbuscular mycorrhizal fungi reshape rhizosphere microbial communities to alleviate phosphorus deficiency in soda-saline soils.Mycorrhiza · 2026Article
- From hijackers to architects: the role of prophages in bacterial genome evolution.Journal of bacteriology · 2026Review
- Chemical inhibition of a CBASS anti-bacteriophage defense.iScience · 2026Article
- Chemical inactivation of a bacterial immune system de-domesticates a temperate phage and promotes its spread.bioRxiv : the preprint server for biology · 2026Article
- Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026Article
- Chemical inhibition of a bacterial immune system.Cell host & microbe · 2026Article
- Diverse Bacterial Anti-Phage Strategies: From the Laboratory to the Clinic.Current issues in molecular biology · 2026Review
- Phage infection fronts trigger early sporulation and viral entrapment in bacterial populations.The ISME journal · 2026Article
- Article
- Metabolome restructuring reveals distinct virocell infection strategies in bacteriophage-host interaction.ISME communications · 2026Article
- First report of a novelFrontiers in microbiology · 2026Article
- A global soil plasmidome resource unveils functional and ecological roles of plasmids in soil microbiomes.Nature communications · 2025Article
- Natural products influence bacteriophage infectivity.Natural product reports · 2025Review
- Exploring phage-host interactions inMicrobiology spectrum · 2025Article
- Fast-growingbioRxiv : the preprint server for biology · 2025Article
- Genome-Wide Insights intoPlants (Basel, Switzerland) · 2025Article
- Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection.Nature microbiology · 2025Article
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7 authors.
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Abstract
To overtake competitors, microbes produce and secrete secondary metabolites that kill neighbouring cells and sequester nutrients. This metabolite-mediated competition probably evolved in complex microbial communities in the presence of viral pathogens. We therefore hypothesized that microbes secrete natural products that make competitors sensitive to phage infection. We used a binary-interaction screen and chemical characterization to identify a secondary metabolite (coelichelin) produced by Streptomyces sp. that sensitizes its soil competitor Bacillus subtilis to phage infection in vitro. The siderophore coelichelin sensitized B. subtilis to a panel of lytic phages (SPO1, SP10, SP50, Goe2) via iron sequestration, which prevented the activation of B. subtilis Spo0A, the master regulator of the stationary phase and sporulation. Metabolomics analysis revealed that other bacterial natural products may also provide phage-mediated competitive advantages to their producers. Overall, this work reveals that synergy between natural products and phages can shape the outcomes of competition between microbes.
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