ArticleNature2025
The sequence-structure-function relationship of intrinsic ERα disorder.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Synonymous codon usage shapes ERα function through specialized translational programs during breast cancer progression.Oncogene · 2026Article
- Autoinhibition of untimely DNA binding by structural disorder in the full-length peroxisome proliferator-activated receptors (PPARs).Nature communications · 2026Article
- RNA polymerase II CTD Ser5 phosphorylation induces competing effects of expansion and compaction.Biophysical journal · 2026Article
- Topological Entanglement in Intrinsically Disordered Proteins: Sequence, Structural, and Functional Determinants.The journal of physical chemistry. B · 2026Article
- The Maximum Growth Temperature for Eukaryotes Is Thermodynamically Driven but Ecologically Contingent.Life (Basel, Switzerland) · 2026Article
- Isotope Decluttering Reduces Spectral Complexity while Maintaining Protein Structure.Analytical chemistry · 2026Article
- In Search of Shape in the Unshaped: Constructing Ensembles of Intrinsically Disordered Proteins.Biophysics reviews · 2026Article
- Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization.Bone research · 2026Article
- Toward a unified framework for determining conformational ensembles of disordered proteins.Nature methods · 2026Review
- Topological Entanglement in Intrinsically Disordered Proteins: Sequence, Structural, and Functional Determinants.bioRxiv : the preprint server for biology · 2026Article
- Single-engineered-residue solvation perturbations regulate global protein architecture and function.Nature communications · 2026Article
- Resolving Conformational Heterogeneity in Intrinsically Disordered Proteins via Experimentally Guided Multi-Replica Simulations.bioRxiv : the preprint server for biology · 2026Article
- The Immunoregulatory Roles of ERα in Breast Cancer: Mechanisms, Crosstalk, and Therapeutic Insights.Journal of cancer prevention · 2026Review
- Site-specific ERα phosphorylation determines sex-dependent metabolic, reproductive, and body-compositional phenotypes in mice.iScience · 2025Article
- The Ensemble Basis of Allostery and Function: Insights from Models of Local Unfolding.Journal of molecular biology · 2025Review
- Structural and Functional Relevance of Charge-Based Transient Interactions inside Intrinsically Disordered Proteins.ACS physical chemistry Au · 2025Article
- ESRP1 drives subtype-specific breast cancer progression through ER-regulated transcriptional programs and EMT-related splicing switch.American journal of cancer research · 2025Article
- Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα-positive breast cancer.Frontiers in oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Zhanwen Du *Case Comprehensive Cancer Center and Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Han Wang *Department of Biochemistry and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Shuqi Luo *Case Comprehensive Cancer Center and Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Zixi YunDepartment of Biochemistry and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Chen WuDepartment of Biochemistry and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Wangfei YangCollege of Integrative Sciences and Arts, Arizona State University, Mesa, AZ, USA.
Matthias BuckDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Wenwei ZhengCollege of Integrative Sciences and Arts, Arizona State University, Mesa, AZ, USA.ORCID 0000-0002-9603-009X
Alexandar L HansenCampus Chemical Instrument Center, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-4474-7141
Hung-Ying KaoDepartment of Biochemistry and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-4535-0314
Sichun YangCase Comprehensive Cancer Center and Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA. sichun.yang@case.edu.ORCID 0000-0002-1726-0576
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3MX-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6MTime resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9MMultifaceted Modeling of Estrogen ReceptorR01GM114056 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI YANG, SICHUN · 2015 to 2024
$3.3MStructure and function of plexin - co-receptor interactionsR01EY029169 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI BUCK, MATTHIAS · 2018 to 2021
$2.1MDecoding the mechanism of disordered protein interactionsR35GM146814 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Wenwei Zheng · 2022 to 2026
$1.8MNCI NIH HHS P30 CA043703NEI NIH HHS R01 EY029169NIGMS NIH HHS P30 GM133893NIGMS NIH HHS P41 GM103622NIGMS NIH HHS R01 GM114056NIGMS NIH HHS R35 GM146814
Abstract
The oestrogen receptor (ER or ERα), a nuclear hormone receptor that drives most breast cancer
Indexed as
Breast NeoplasmsEstrogen Receptor alphaIntrinsically Disordered ProteinsCell ProliferationFemaleHumansHydrophobic and Hydrophilic InteractionsModels, MolecularMutationPhosphorylationProtein DomainsScattering, Small AngleSerineStructure-Activity RelationshipX-Ray DiffractionESR1 protein, humanEstrogen Receptor alphaIntrinsically Disordered ProteinsSerine
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.