Evidence map›Paper›PMID 39779855›Full record

ArticleNature2025

RNA control of reverse transcription in a diversity-generating retroelement.

Sumit Handa, Tapan Biswas, Jeet Chakraborty, Gourisankar Ghosh, Blair G Paul, Partho Ghosh

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sumit Handa *Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Tapan Biswas *Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Jeet ChakrabortyDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Gourisankar GhoshDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6311-7351
Blair G PaulMarine Biological Laboratory, Josephine Bay Paul Center, Woods Hole, MA, USA.ORCID 0000-0002-5738-5568
Partho GhoshDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA. pghosh@ucsd.edu.ORCID 0000-0003-0254-5218

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
MICROSCOPY &IMAGE ANALYSIS OF UNSTAINED MACROMOLECULESR01GM033050 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAKER, TIMOTHY S · 1985 to 2017
$4.3M
Suppressing Inflammation by Blocking IKK OligomerR01AI163327 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOURISANKAR GHOSH · 2022 to 2026
$2.6M
Selective infidelity in diversity-generating retroelementsR01GM132720 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PARTHO · 2020 to 2023
$1.3M
NIAID NIH HHS R01 AI163327NIGMS NIH HHS R01 GM033050NIGMS NIH HHS R01 GM132720NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Diversity-generating retroelements (DGRs) create massive protein sequence variation (up to 10

Indexed as

Genetic VariationRetroelementsReverse TranscriptionRNABacteriophagesBordetellaCryoelectron MicroscopyModels, MolecularRibonucleoproteinsRNA-Directed DNA PolymeraseViral ProteinsRetroelementsRibonucleoproteinsRNARNA-Directed DNA PolymeraseViral Proteins

Identifiers

PMID39779855
PMCPMC11995886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.