Evidence map›Paper›PMID 39779844›Full record

ArticleNature2025

Structural basis for the conformational protection of nitrogenase from O

Sarah M Narehood, Brian D Cook, Suppachai Srisantitham, Vanessa H Eng, Angela A Shiau, Kelly L McGuire, R David Britt, Mark A Herzik, F Akif Tezcan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah M NarehoodDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Brian D CookDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Suppachai SrisantithamDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Vanessa H EngDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
Angela A ShiauDepartment of Chemistry, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-4395-9847
Kelly L McGuireDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.
R David BrittDepartment of Chemistry, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0889-8436
Mark A HerzikDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. mherzik@ucsd.edu.ORCID 0000-0001-6653-6682
F Akif TezcanDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. tezcan@ucsd.edu.ORCID 0000-0002-4733-6500

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Towards an Atomistic Understanding of Mitochondrial Protein Biogenesis (Equipment Supplement)R35GM138206 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HERZIK, MARK ANTHONY · 2020 to 2024
$2.1M
Mechanism of Energy Transduction and Substrate Activation in Biological Nitrogen FixationR01GM148607 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI F. Akif Tezcan · 2023 to 2026
$1.3M
Chameleon Sample Preparation Device for Cryo-EMS10OD032471 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LESCHZINER, ANDRES · 2022 to 2022
$420k
NIBIB NIH HHS T32 EB009380NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R01 GM148607NIGMS NIH HHS R35 GM126961NIGMS NIH HHS R35 GM138206NIH HHS S10 OD032471
6 · The paper itself

Abstract

The low reduction potentials required for the reduction of dinitrogen (N

Indexed as

Azotobacter vinelandiiNitrogenaseOxygenCrystallography, X-RayModels, MolecularOxidation-ReductionProtein ConformationNitrogenaseOxygen

Identifiers

PMID39779844
PMCPMC11812610

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.