ReviewNature reviews. Neurology2025
Sleep and circadian disturbances in children with neurodevelopmental disorders.
Review in Nature reviews. Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07122388 ("Retrospective Study on the Evaluation of Sleep Habits, Sleep Macrostructure and Microstructure in Children and Adolescents With Autism Spectrum Disorder), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Retrospective Study on the Evaluation of Sleep Habits, Sleep Macrostructure and Microstructure in Children and Adolescents With Autism Spectrum Disorder: Association With Behavioral Variables and Parental Stress"
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Invisible Harms, Visible Benefits? Adverse Event Reporting in Physical Activity Interventions for Neurodevelopmental Disorders: A Meta-analysis and Critical Appraisal.Sports medicine - open · 2026Pooled it
- The prevalence of neurodevelopmental disorders in Smith-Magenis Syndrome: a PRISMA compliant systematic review.Journal of neurodevelopmental disorders · 2026Pooled it
- Effect of virtual reality-based training on postural balance in children and adolescents with neurodevelopmental disorders: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Intermittent Theta Burst Stimulation Improves Sleep in Autism Spectrum Disorder by Reorganizing Overlapping Brain Networks With Neurochemical and Transcriptomic Signatures: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- Mediating role of sleep duration in the association between problematic media use and sleep disturbance in children with neurodevelopmental disabilities.Irish journal of medical science · 2026Article
- Sleep in Young Children With Autism, ADHD and Combined Presentations.Autism research : official journal of the International Society for Autism Research · 2026Article
- Sleep in Children with Neurodevelopmental Disorders: From Diagnostic Labels to Phenotype-directed Care.Current neurology and neuroscience reports · 2026Review
- Sleep Disorders and the Influence of Maternal Age in Young Children With Autism Spectrum Disorder: A Retrospective Cross-sectional Study.Journal of autism and developmental disorders · 2026Article
- Unveiling sleep disturbances in KCNB1-related disorders: Insights from a cohort of 78 individuals.Epilepsia open · 2026Article
- Article
- Dihydroergotamine alleviates circadian rhythm disorders through predicted interaction with to CRY1.Molecular diversity · 2026Article
- Rest-activity patterns across development in two mouse models of autism and epilepsy.Epilepsia open · 2026Article
- De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms.American journal of human genetics · 2026Article
- Histomorphometrical Analyses of the Mouse Suprachiasmatic Nucleus.Bio-protocol · 2026Article
- Understanding the Complexity of Sleep Disturbances in ASD: From Mechanisms to Management.Diagnostics (Basel, Switzerland) · 2026Review
- Reciprocal regulation between autism risk gene POGZ and circadian clock.JCI insight · 2026Article
- Age-Related Characteristics of SYT1-Associated Neurodevelopmental Disorder.Annals of clinical and translational neurology · 2026Article
- Nighttime sleep promotes mechanosensory habituation inbioRxiv : the preprint server for biology · 2026Article
- Tracing the Evolution of Sleep-Related Behavioural Outcomes Research in Autistic Children: A Scientometric Review.Journal of autism and developmental disorders · 2026Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is essential for brain development and overall health, particularly in children with neurodevelopmental disorders (NDDs). Sleep disruptions can considerably impact brain structure and function, leading to dysfunction of neurotransmitter systems, metabolism, hormonal balance and inflammatory processes, potentially contributing to the pathophysiology of NDDs. This Review examines the prevalence, types and mechanisms of sleep disturbances in children with NDDs, including autism spectrum disorder, attention-deficit hyperactivity disorder and various genetic syndromes. Common sleep disorders in these populations include insomnia, hypersomnia, circadian rhythm disorders, sleep-related breathing disorders and parasomnias, with underlying factors often involving genetic, neurobiological, environmental and neurophysiological influences. Sleep problems such as insomnia, night awakenings and sleep fragmentation are closely linked to both internalizing symptoms such as anxiety and depression, and externalizing behaviours such as hyperactivity and aggression. Assessment of sleep in children with NDDs presents unique challenges owing to communication difficulties, comorbid conditions and altered sensory processing. The Review underscores the importance of further research to unravel the complex interactions between sleep and neurodevelopment, advocating for longitudinal studies and the identification of predictive biomarkers. Understanding and addressing sleep disturbances in NDDs is crucial for improving developmental outcomes and the overall quality of life for affected individuals and their families.
Indexed as
Identifiers
39779841What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.