Evidence map›Paper›PMID 39779757›Full record

Articlenpj aging2025

Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy.

Michio Sato, Daisuke Torigoe, Yuya Kinoshita, Momoka Cyuman, Chitoku Toda, Masaru Sato, Kazutaka Ikeda, Tsuyoshi Kadomatsu, Haruki Horiguchi, Jun Morinaga and 8 more

Erratum issuedAbstract read
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In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Michio SatoDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0001-9339-1642
Daisuke TorigoeDivision of Laboratory Animal Science, Institute of Resource Development and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.
Yuya KinoshitaDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Momoka CyumanDivision of Laboratory Animal Science, Institute of Resource Development and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.
Chitoku TodaDepartment of Neuroscience for Metabolic Control, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Masaru SatoLaboratory of Biomolecule Analysis, Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan.
Kazutaka IkedaLaboratory of Biomolecule Analysis, Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan.
Tsuyoshi KadomatsuDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Haruki HoriguchiDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Jun MorinagaDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Hirotaka FukamiDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-7375-0748
Taichi SugizakiDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Keishi MiyataDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Ryoko KusabaDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Yusuke OkadomeDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Eiji MatsunagaDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Koichi NodeDepartment of Cardiovascular Medicine, School of Medicine, Saga University, Saga, Japan.
Yuichi OikeDepartment of Molecular Genetics, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.ORCID http://orcid.org/0000-0003-3245-5395

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) Grant 22K11727MEXT | Japan Society for the Promotion of Science (JSPS) Grant 23K07511
6 · The paper itself

Abstract

Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergothioneine (EGT), an antioxidant with potential health benefits. In this study, we assessed the possibility that long-term consumption of Tamogi-take mushrooms might attenuate age-related decline in cardiac and vascular endothelial function in mice. We found that long-term intake of Tamogi-take mushrooms significantly maintained cardiac and vascular endothelial function and improved exercise tolerance in mice. Long-term mushroom consumption also increased levels of Nrf2 (Nuclear factor E2-related factor 2) protein in heart tissues and increased translation of HO-1 (Heme Oxygenase 1) proteins, which have antioxidant effects in heart and aortic tissues. Finally, long-term Tamogi-take mushroom consumption inhibited ROS accumulation with aging and reduced expression of inflammatory biomarkers. We conclude that ingestion of Tamogi-take mushrooms could serve as a dietary intervention to promote cardiovascular health, support healthy aging and slow the progression of age-related diseases.

Identifiers

PMID39779757
PMCPMC11711650

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.