Evidence map›Paper›PMID 39779653›Full record

ArticleMolecular imaging and biology2025

PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [

Jiwei Gu, Ming-Qiang Zheng, Daniel Holden, Krista Fowles, Lin Qiu, Zachary Felchner, Li Zhang, Jim Ropchan, Robert J Gropler, Richard E Carson and 3 more

Abstract read
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. First evaluation in multiple sclerosis using PET tracer [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jiwei GuYale PET Center, Yale School of Medicine, New Haven, USA.
Ming-Qiang ZhengYale PET Center, Yale School of Medicine, New Haven, USA.
Daniel HoldenYale PET Center, Yale School of Medicine, New Haven, USA.
Krista FowlesYale PET Center, Yale School of Medicine, New Haven, USA.
Lin QiuMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, USA.
Zachary FelchnerYale PET Center, Yale School of Medicine, New Haven, USA.
Li ZhangYale PET Center, Yale School of Medicine, New Haven, USA.
Jim RopchanYale PET Center, Yale School of Medicine, New Haven, USA.
Robert J GroplerMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, USA.
Richard E CarsonYale PET Center, Yale School of Medicine, New Haven, USA.
Zhude TuMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, USA.
Yiyun HuangYale PET Center, Yale School of Medicine, New Haven, USA.
Ansel T HillmerYale PET Center, Yale School of Medicine, New Haven, USA. hillmera@med.umich.edu.ORCID http://orcid.org/0000-0002-8105-1381

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Yongjian Liu · 2018 to 2026
$12.7M
Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MACH, ROBERT H · 2019 to 2023
$9.4M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
Intramural Research Program, National Institute on Drug Abuse P30DA046345NIBIB NIH HHS P41 EB025815NIBIB NIH HHS P41EB025815NIDA NIH HHS P30 DA046345NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988NINDS NIH HHS R01NS103988NINDS NIH HHS R01 NS134586NINDS NIH HHS R01NS134586
6 · The paper itself

Abstract

purposeThe sphingosine-1-phosphate receptor-1 (S1PR PROCEDURES: [

results[

conclusions[

Indexed as

Fluorine RadioisotopesPositron-Emission TomographySphingosine-1-Phosphate ReceptorsAnimalsBrainMacaca mulattaMaleRadiopharmaceuticalsTissue DistributionFluorine RadioisotopesRadiopharmaceuticalsSphingosine-1-Phosphate ReceptorsEndotoxinPET neuroimagingSphingosine 1 phosphate receptor

Identifiers

PMID39779653
PMCPMC12207061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.