ArticleAAPS PharmSciTech2025
Mechanistic Insights Underlying the Drug Release and Skin Permeation of Guanfacine Transdermal Patch with Various Acrylic Pressure-Sensitive Adhesives.
Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acrylic pressure-sensitive adhesives (PSAs) are widely applied in transdermal drug delivery systems (TDDS). However, the molecular mechanisms underlying the effect of functional groups of PSAs on drug release and transdermal permeation properties remain insufficiently clear. In this study, we investigated the effect of acrylic PSAs' functional groups on the in vitro release and transdermal permeation properties of a model drug guanfacine (GFC). The rates of release and permeation were hydroxyl PSA (PSA-OH) > non-functional group PSA (PSA-None) > carboxyl PSA (PSA-COOH). Thermal analysis, molecular modeling, Raman spectroscopy, and FTIR were employed to characterize the drug-PSA interactions. The strength of the interaction force between GFC and PSA-None was determined to be negligible. The primary amino of GFC formed a medium-strength hydrogen bond with the hydroxyl of PSA-OH and a strong ionic interaction with the carboxyl of PSA-COOH. Compared to PSA-None, PSA-OH featured a weaker mechanical strength, a higher rheological phase shift angle (δ), and a lower glass transition temperature (T
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Registered trials
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