Evidence map›Paper›PMID 39779622›Full record

ArticleAIDS and behavior2025

The Impacts of Substance Use and Depression on HIV Pre-Exposure Prophylaxis Use and Adherence Among Sexual and Gender Minority Adolescents and Young Adults in the Keeping it LITE Cohort.

Sara N Levintow, Pedro A Serrano, Courtney N Maierhofer, Audrey L French, Sybil Hosek, Kimberly A Powers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara N LevintowDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. levintow@email.unc.edu.ORCID http://orcid.org/0000-0001-5558-526X
Pedro A SerranoRuth M. Rothstein CORE Center, Cook County Health, Chicago, IL, USA.
Courtney N MaierhoferDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Audrey L FrenchDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Sybil HosekDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Kimberly A PowersDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Keeping it LITE: Exploring HIV Risk in Vulnerable Youth with Limited InteractionUH3AI133676 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI FRENCH, AUDREY, HOSEK, SYBIL · 2019 to 2021
$2.1M
Keeping it LITE: Exploring HIV Risk in Vulnerable Youth with Limited InteractionUG3AI133676 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI FRENCH, AUDREY, HOSEK, SYBIL · 2017 to 2018
$1.5M
Investigating SARS-CoV-2 transmission dynamics in jails to address the COVID-19 public health emergencyK01AI171088 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEVINTOW, SARA NICOLE · 2022 to 2024
$405k
NIAID, NICHD, and NIMH UG3/UH3 AI133676NIAID NIH HHS K01 AI171088NIAID NIH HHS UG3 AI133676NIAID NIH HHS UH3 AI133676
6 · The paper itself

Abstract

Substance use and depression are prevalent in sexual and gender minorities (SGM), but evidence about their impacts on HIV pre-exposure prophylaxis (PrEP) use is mixed. We assessed these impacts in a US-based cohort of 3,330 young SGM who tested negative for HIV and completed baseline and semiannual assessments on substance use (cocaine, methamphetamine, or heroin), depression, and PrEP use and adherence. We estimated prevalence differences (PDs) to compare baseline and 12-month PrEP use and adherence between participants with and without substance use and depression, separately and jointly. At baseline, 8% of participants reported substance use and depression, 7% reported substance use only, 38% reported depression only, and 47% reported neither. PrEP use was reported by 22%, with 78% reporting prior-day adherence. Compared to participants without depression or substance use, participants with substance use alone were more likely to report PrEP use at baseline (PD = 18.9; 95% CI: 7.6, 30.2) and 12 months (PD = 15.9, 95% CI: 5.1, 26.7), without adherence differences. Depression alone was associated with lower baseline PrEP use (PD=-3.6, 95% CI: -6.7, -0.4) and adherence (PD=-10.0, 95% CI: -18.4, -1.6), but associations attenuated over 12 months. Those with both substance use and depression (vs. neither) reported higher baseline PrEP use (PD = 6.5, 95% CI: -0.6, 13.5) and lower adherence (PD=-12.9, 95% CI: -26.2, 0.5), with associations weakening over 12 months. Substance use and depression had opposing relationships with PrEP use and adherence. In addition to its mental health benefits, depression treatment may improve PrEP uptake and adherence in young SGM.

Indexed as

Anti-HIV AgentsDepressionHIV InfectionsMedication AdherencePre-Exposure ProphylaxisSexual and Gender MinoritiesSubstance-Related DisordersAdolescentAdultCohort StudiesFemaleHumansMalePrevalenceUnited StatesYoung AdultAnti-HIV AgentsBisexualDepressive symptomsDrug useGayHIV preventionLesbianMen who have sex with menQueer or questioningTransgenderYouth

Identifiers

PMID39779622
PMCPMC12218902

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.