Evidence map›Paper›PMID 39779611›Full record

ArticleInternational journal of colorectal disease2025

Treatment outcomes and prognostic factors in patients with colorectal cancer and synchronous lung metastases in the conversion therapy era.

Hiroaki Nozawa, Nobumi Suzuki, Tatsuya Tsushima, Koji Murono, Kazuhito Sasaki, Shigenobu Emoto, Mitsuhiro Fujishiro, Masaaki Sato, Soichiro Ishihara

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In one paragraph

Article in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroaki NozawaDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. hiroanozawa@yahoo.co.jp.ORCID http://orcid.org/0000-0002-7891-5986
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tatsuya TsushimaDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Koji MuronoDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Kazuhito SasakiDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Shigenobu EmotoDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masaaki SatoThoracic Surgery Department, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Japanese Grade Classification based on the status of pulmonary and mesenteric nodal metastases and the presence of extrapulmonary metastases had a prognostic value in patients with colorectal lung metastases previously. Because the survival of such patients has improved in the era of conversion therapy, this classification needs to be reaudited.

methodsThis study reviewed the treatment sequences of 126 colorectal cancer patients with synchronous lung metastases between 2010 and 2022 at our hospital. Patients were divided into Japanese Classification Grade A, B, and C. Prognostic factors for overall survival (OS) were analyzed.

resultsThirty patients were initially diagnosed with resectable disease. Among these, 6 (35%) of 17 patients who were scheduled to undergo upfront surgery developed unresectable disease. In contrast, 3 (23%) of 13 patients receiving neoadjuvant therapy could not undergo curative resection. Twelve (13%) of 96 patients with initially unresectable metastases underwent conversion to complete resection after systemic therapy. On multivariate analysis, curative resection and H3 (> 5 liver metastases and maximum diameter > 5 cm) at diagnosis were independent prognostic factors, whereas the Japanese Grade Classification was not associated with OS.

conclusionInstead of the Japanese classification, a new prognostic classification incorporating H3 should be established.

Indexed as

Colorectal NeoplasmsLung NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedMultivariate AnalysisPrognosisTreatment OutcomeColorectal cancerConversion therapyLiver metastasisLung metastasesPrognostic factor

Identifiers

PMID39779611
PMCPMC11711644

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