Evidence map›Paper›PMID 39779591›Full record

ArticleDigestive diseases and sciences2025

Overall and Regional Colonic Transit Abnormalities in Elderly Patients with Constipation.

David Yi Yang, Camille Lupianez-Merly, Kara Jencks, Duane Burton, Michael Ryks, Michael Camilleri

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

David Yi YangClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA.
Camille Lupianez-MerlyClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA.
Kara JencksClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA.
Duane BurtonClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA.
Michael RyksClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA.
Michael CamilleriClinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA. camilleri.michael@mayo.edu.

Funding

MULTIDISCRIPLINARY TRAINING IN DIGESTIVE DISEASEST32DK007198 · NIDDK · MAYO CLINIC ROCHESTER · PI Harmeet Malhi · 1986 to 2026
$8.9M
NIDDK NIH HHS T32 DK007198
6 · The paper itself

Abstract

objectiveChronic constipation (CC) more frequently affects the elderly; pelvic floor dysfunction (PFD) may confuse the appraisal of the pathophysiology of CC. The aim was to characterize colonic transit (CT) in elderly with CC with/without PFD.

designWe conducted retrospective medical records review of 191 patients ≥ 65 years who underwent scintigraphic CT for assessing CC. Overall CT and distribution of isotopes in 4 colonic regions and stool were compared with 179 healthy controls < 65 years and 183 CC < 66 years. Presence of PFD, comorbidities, and concomitant medications were documented. Data shown are median (IQR).

resultsElderly CC patients were predominantly female (69.3%), aged 70 (67,74) years, with PFD in 56.9%. Elderly CC had overall slower CT (geometric center) at 48 h [2.5 (2.0,3.48)] compared to controls [3.79 (2.69,4.69)], but overall and proximal CT were not different compared to CC < 66 years. Combined ascending and transverse colon (AC + TC) at 48 h was lower in elderly CC [51.1 (14.4,76.5)] % compared to healthy controls [86.5 (53.6, 100)% p < 0.001]. There was no difference in overall CT among elderly CC with and without PFD. Among groups with PFD, the elderly CC (compared to CC < 66y) had higher AC + TC emptying at 24 h (8.6% [IQR 0.0-30.2] vs 0.3% [0.0-20.6] p = 0.042), but not at 48 h.

conclusionOverall and proximal CT of elderly with CC was slower to healthy controls, but similar to adults < 66 years with CC. In the 56.9% elderly CC with PFD, overall CT and AC + TC emptying were similar to those without PFD.

Indexed as

ColonConstipationGastrointestinal TransitPelvic Floor DisordersAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedRadionuclide ImagingRetrospective StudiesColonic transitPelvic floor dysfunctionProximal emptying

Identifiers

PMID39779591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.