Evidence map›Paper›PMID 39779570›Full record

ArticleAnti-cancer agents in medicinal chemistry2025

Anti-metastasis Effects and Mechanism of Action of Curcumin Analog (2E,6E)-2,6-bis(2,3-dimethoxybenzylidene) Cyclohexanone (DMCH) on the SW620 Colorectal Cancer Cell Line.

Nurul Fattin Che Rahim, Yazmin Hussin, Muhammad Nazirul Mubin Aziz, Mas Jaffri Masarudin, Shafinaz Abd Gani, Muhammad Nadeem Akhtar, Nik Mohd Afizan Nik Abd Rahman, Noorjahan Banu Alitheen

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Article in Anti-cancer agents in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nurul Fattin Che RahimDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, 43400, Selangor, Malaysia.
Yazmin HussinDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, 43400, Selangor, Malaysia.
Muhammad Nazirul Mubin AzizFaculty of Dentistry, AIMST University, Bedong, 08100, Kedah, Malaysia.
Mas Jaffri MasarudinDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, 43400, Selangor, Malaysia.
Shafinaz Abd GaniDepartment of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, 43400, Selangor, Malaysia.
Muhammad Nadeem AkhtarDepartment of Chemistry, Ghazi University, Dera Ghazi Khan, 32200, Pakistan.
Nik Mohd Afizan Nik Abd RahmanDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, 43400, Selangor, Malaysia.
Noorjahan Banu AlitheenDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, 43400, Selangor, Malaysia.

Funding

Ministry of Higher Education of Malaysia RDU 150109, 150349
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is the second-leading cause of cancer-related deaths. Curcumin has been reported to have suppressive effects in CRC and to address the physiological limitations of curcumin, a chemically synthesized curcuminoid analog, known as (2E,6E)-2,6-Bis (2,3-Dimethoxy benzylidine) cyclohexanone (DMCH), was developed and the anti-metastatic and anti-angiogenic properties of DMCH in colorectal cell line, SW620 were examined.

methodsThe anti-metastatic effects of DMCH were examined in the SW620 cell line by scratch assay, migration, and invasion assay, while for anti-angiogenesis properties of the cells, the mouse aortic ring assay and Human Umbilical Vein Endothelial Cells (HUVEC) assay were conducted. The mechanism of action was determined by microarray-based gene expression and protein analyses.

resultsThe wound healing assay demonstrated that wound closure was decreased from 63.63 ± 1.44% at IC

conclusionDMCH could be a potential anti-cancer agent due to its capability to impede metastasis and angiogenesis activities of the SW620 colorectal cancer cell line in vitro via regulating genes and protein in metastases and angiogenesis-related signalling pathways.

Indexed as

Angiogenesis InhibitorsAntineoplastic AgentsColorectal NeoplasmsCurcuminCyclohexanonesAnimalsCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansHuman Umbilical Vein Endothelial CellsMiceMolecular StructureStructure-Activity RelationshipAngiogenesis InhibitorsAntineoplastic AgentsCurcuminCyclohexanonesangiogenesisColon cancercurcumin analogDMCHepidermal growth factor receptor (EGFR).metastasis

Identifiers

PMID39779570

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.