Evidence map›Paper›PMID 39779560›Full record

ArticleCurrent medicinal chemistry2025

An Azomethine Derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2) Ameliorated 7,12-dimethylbenz(a)anthracene-induced Mammary Carcinoma through Nrf2-Keap1-HO-1 Pathway.

Reetuparna Acharya, Pran Kishore Deb, Shakti Prasad Pattanayak

Abstract read
PubMed Publisher
In one paragraph

Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reetuparna AcharyaDivision of Advanced Pharmacology, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, 835215, Ranchi, India.
Pran Kishore DebDivision of Pharmaceutical Medicinal Chemistry, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, 835215, Ranchi, India.ORCID 0000-0002-8650-2874
Shakti Prasad PattanayakDepartment of Biochemistry, School of Medicine, Case Western Reserve University, Woods building, W437, 2109 Adelbert Road, Cleaveland, Ohio, 44106, USA.ORCID 0000-0002-1629-2648

Funding

BIT Mesra, Ranchi BIT/DRIE/SMS/2024-25/1877
6 · The paper itself

Abstract

aimsThe aim of this study is the evaluation of an Azomethine derivative, BCS2, for its antioxidant and anti-tumor activities against mammary carcinoma through the Nrf2- Keap1-HO-1 pathway.

backgroundThe global prevalence of breast cancer is rising at an alarming rate. The facilitation of abnormal cell proliferation in mammary carcinoma occurs due to the disruption of signaling pathways that balance pro- and antioxidant status, thereby producing oxidative stress that disrupts genomic stability. Therefore, introducing a potent antioxidant molecule with antitumor activity is of paramount importance for treating breast cancer.

objectiveSynthesis, characterization, and

methodsAn azomethine derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2), was synthesized and characterized based on its spectral data. The cytotoxic potential was observed on breast cancer cells, MCF-7, MDA-MB-231, and MDA-MB-468. The

resultsBCS2 showed remarkable cytotoxic activity on MCF-7 cells followed by MDA-MB- 231 and MDA-MB-468 cells having an IC

conclusionThe study revealed BCS2's potent antioxidant and antitumor potential against mammary carcinoma through the Nrf2-Keap1-HO-1 signaling pathway.

Indexed as

Antineoplastic AgentsAntioxidantsBreast NeoplasmsMammary Neoplasms, ExperimentalThiosemicarbazones9,10-Dimethyl-1,2-benzanthraceneAnimalsCell ProliferationFemaleHeme Oxygenase-1HumansKelch-Like ECH-Associated Protein 1Molecular StructureNF-E2-Related Factor 2RatsRats, Sprague-Dawley9,10-Dimethyl-1,2-benzanthraceneAntineoplastic AgentsAntioxidantsHeme Oxygenase-1KEAP1 protein, ratKelch-Like ECH-Associated Protein 1Nfe2l2 protein, ratNF-E2-Related Factor 2Thiosemicarbazones12-dimethylbenz(a)anthracene7breast cancerELISA.Keap1NF-κBNrf2

Identifiers

PMID39779560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.