Evidence map›Paper›PMID 39779537›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Experiences of patients with metastatic colorectal cancer participating in a supervised exercise intervention during chemotherapy.

Calvin G Brouwer, Marieke R Ten Tusscher, Bente M de Roos, Elske C Gootjes, Tineke E Buffart, Kathelijn S Versteeg, Isa H Mast, Mirte M Streppel, Inge M Werter, Anne M May and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04754672 (Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04754672 narecruitingnot on this map

Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome (AMICO). The Effects of Exercise on Chemotherapy Dose Modification and Progression Free Survival in Patients With Metastatic Colorectal Cancer

TypeinterventionalSponsorRadboud University Medical CenterRan2021 to 2026Enrolled228ConditionsColorectal Cancer, Chemotherapeutic Toxicity, Survivorship, LifestyleArmsContinuous aerobic and resistance exercise intervention, Continuous aerobic and aerobic interval exercise intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Calvin G Brouwer *Department of Medical BioSciences (HP 928), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Marieke R Ten Tusscher *Department of Medical BioSciences (HP 928), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Bente M de RoosDepartment of Medical BioSciences (HP 928), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Elske C GootjesDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Tineke E BuffartDepartment of Medical Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Kathelijn S VersteegDepartment of Medical Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Isa H MastDepartment of Medical BioSciences (HP 928), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Mirte M StreppelDepartment of Medical Oncology, Amphia Hospital, Breda, The Netherlands.
Inge M WerterDepartment of Medical Oncology/Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
Anne M MayDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Henk M W VerheulDepartment of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands.
Laurien M BuffartDepartment of Medical BioSciences (HP 928), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands. Laurien.buffart@radboudumc.nl.
AMICO Consortium

Funding

Cancer Center Amsterdam CCA2020-1-20ZonMw 09150171910017
6 · The paper itself

Abstract

purposePatients with metastatic colorectal cancer (mCRC) undergoing systemic treatment often experience toxicities. Although exercise may improve physical fitness and quality of life and counteract treatment toxicity, knowledge in patients with mCRC is limited. The ongoing randomized controlled AMICO trial evaluates the effects of supervised exercise on clinical outcomes. The present qualitative study was a pre-planned part of this trial aiming to capture adherence, satisfaction, and perceived effects of exercise among patients with mCRC.

methodsPatients with mCRC receiving first-line systemic treatment were randomized (1:1:1) to a control group or one of two supervised exercise arms including continuous aerobic exercise with either resistance exercises or high-intensity interval training. Semi-structured interviews with patients in the exercise arms were transcribed verbatim and thematically analyzed. Descriptive data on adherence (exercise logs) and satisfaction (questionnaire) was collected to complement and contextualize the qualitative findings.

resultsTwenty-one patients were interviewed. Median exercise attendance was 67% [IQR 35-91], and the median satisfaction score was 8 [IQR 8-9] out of 10. Patients valued the guidance and knowledge of the physical therapist and expressed interindividual preferences regarding training content. Patients experienced that exercise improved their physical and mental wellbeing and helped them to endure treatment. Perceived exercise barriers were treatment toxicity, physical problems, and hospital appointments. Perceived exercise facilitators included adequate tailoring and internal or external motivation.

conclusionPatients with mCRC appreciated exercise during systemic treatment and perceived several beneficial effects, both physically and mentally. Exercise attendance varied and barriers were mainly treatment- and disease-related.

trial registrationClinical trial. GOV ID: NCT04754672. Date of registration: 04-12-2020.

Indexed as

Colorectal NeoplasmsExercise TherapyPatient SatisfactionQuality of LifeAgedAntineoplastic AgentsExerciseFemaleHumansMaleMiddle AgedNeoplasm MetastasisPatient ComplianceQualitative ResearchResistance TrainingSurveys and QuestionnairesAntineoplastic AgentsExercisePhysical activityQualitative studySystemic treatmentTreatment tolerability

Identifiers

PMID39779537
PMCPMC11711133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.