Evidence map›Paper›PMID 39779517›Full record

Observational studyNeurosurgical review2025

Minimally invasive management of cervical spondylodiscitis. A multicenter experience.

Felix Kossi Kouma Segbedji, Charles-Henry Mallereau, Guillaume Dannhoff, Victoria Dembour, Helene Cebula, Mario Ganau, Julien Todeschi, Alfonso Cerase, Vitaliano Francesco Muzii, Alessandro Zalaffi and 9 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Anterior debridement, reconstruction, and fusion for cervical brucellosis spondylitis with epidural abscess: a single-center experience of 30 patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Felix Kossi Kouma SegbedjiNeurosurgery Department Sylvanus, Olympio University Hospital, Lomé, Togo.
Charles-Henry MallereauNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France. Mallereau.charles@gmail.com.
Guillaume DannhoffNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France.
Victoria DembourNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France.
Helene CebulaNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France.
Mario GanauNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France.
Julien TodeschiNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France.
Alfonso CeraseDiagnostic and Therapeutic Neuroradiology Department, Siena University Hospital, Siena, Italy.
Vitaliano Francesco MuziiNeurosurgery Unit of "Dipartimento Di Scienze MedicheChirurgiche E Neuroscienze, Siena University Hospital, Siena, Italy.
Alessandro ZalaffiNeurosurgery Unit of "Dipartimento Di Scienze MedicheChirurgiche E Neuroscienze, Siena University Hospital, Siena, Italy.
Biagio Roberto CarangeloNeurosurgery Unit of "Dipartimento Di Scienze MedicheChirurgiche E Neuroscienze, Siena University Hospital, Siena, Italy.
Franco MoruzziNeurosurgery Unit of "Dipartimento Di Scienze MedicheChirurgiche E Neuroscienze, Siena University Hospital, Siena, Italy.
Giorgio SpatolaNeurosurgery department, Istituto Osepedaliero Fondazione Poliambulanza Brescia, Brescia, Italy.
Ismael ZaedNeurosurgery department Lugano University Hospital, Lugano, Switzerland.
Andrea CardiaNeurosurgery department Lugano University Hospital, Lugano, Switzerland.
Antonio RomanoNeurosurgery department Parma University Hospital, Parma, Italy.
Paola CastellaniNeuro ITU, Siena University Hospital, Siena, Italy.
Francesca TarantinoNeuro ITU, Siena University Hospital, Siena, Italy.
Salvatore ChibbaroNeurosurgery department Strasbourg University Hospital, Hautepierre University Hospital, 2 Avenue de Molière, Strasbourg, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgent etiological diagnosis represents the main management objective of cervical spondylodiscitis (CSD) to start as soon as possible antibiotic treatment to prevent neurological deterioration. The present study aimed to evaluate a multicenter experience implementing a minimally invasive surgical approach (MISA) to manage CSD such pathology vs the most complex and aggressive surgical strategies currently used.This retrospective multicenter study used a database of 70 patients from five European neurosurgical centers. Patients with primary CSD underwent MISA via a limited funnel shaped cervical microdiscectomy with 4-mm anterior and 6-mm posterior longitudinal ligaments incision, PUS drainage, and extensive washing of the interbody and epidural space without fusion. Diagnosis was confirmed by clinical, imaging, laboratory, and perioperative histopathology and bacteriology.Of the 70 patients, 41 were men (58,5%), with an average age of 47.67 years. Severe neck pain affected 45 patients, while 51 had single-level cervical spondylodiscitis, 14 had double-level, and 5 had triple-level involvement. Staphylococcus aureus was identified in 49 cases. Each patient received a mean of three months of antibiotics. Inflammatory markers (C-reactive protein) were moderate for four weeks, then normalized by 8-12 weeks, except in one recurrence. After an average 48-month follow-up, all patients fully recovered without neurological deficit, spinal instability, or kyphotic deformity. Radiological exams confirmed bony fusion, with no recurrences of infection. MISA treatment offers a valuable, stable, and less invasive option for treating CSD, effectively identifying causative microorganisms and decompressing the spinal cord, leading to excellent patient outcomes.

Indexed as

Cervical VertebraeDiscitisMinimally Invasive Surgical ProceduresAdultAgedAnti-Bacterial AgentsDiskectomyFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAnti-Bacterial AgentsCervical spondylodiscitisKyphotic deformationMinimally invasive surgical treatmentSpine instabilityStaphylococcus aureus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.