Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
The effect of hand and foot exercises on peripheral neuropathy and quality of life in women with breast cancer: a randomized controlled trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06055088 (The Effect of Hand-Foot Exercises on Peripheral Neuropathy in Women With Breast Cancer Receiving Neurotoxic Chemotherapy), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Hand-Foot Exercises on Peripheral Neuropathy in Women With Breast Cancer Receiving Neurotoxic Chemotherapy
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and influencing factors of chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Effects of Integrative Approaches for the Management of Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients: A Systematic Review of Randomized Controlled Trials and Quasi-Experimental Studies.Journal of pain research · 2026Review
- Effectiveness of Exercise and Physiotherapy in Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePeripheral neuropathy is one of the most devastating symptoms experienced by the patients. Supportive and holistic care interventions are crucial to help these patients. The aim of this study is to determine the effects of hand and foot exercises on chemotherapy-induced peripheral neuropathy and quality of life in women with breast cancer.
methodsThe sample of this randomized controlled trial study consisted of 79 women with breast cancer who underwent taxane-group chemotherapy in a hospital. The women diagnosed with grade 1 or higher peripheral neuropathy were included in the study. Women were divided into three groups as exercises with a massage ball, exercises with a stress ball, and control group. Hand and foot exercises last for 8 weeks. Data were collected using the Information Form, the Common Terminology Criteria for Adverse Events, and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire.
resultsThe severity of neuropathy decreased significantly in both massage ball and stress ball exercise groups compared to the control group (p < 0.05). The group and time interaction was statistically significant in fatigue, pain, and motor symptoms (p < 0.05).
conclusionWomen with breast cancer who undergo neurotoxic chemotherapy are thought to alleviate neuropathy symptoms and enhance their quality of life through simple home-based exercises. Nonpharmacological, applicable interventions, such as hand-foot exercises, can be integrated into patient education and care practices during the chemotherapy process.
trial registrationClinicalTrails.gov (Registration number: NCT06055088. registered on 01 June 2023).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.