Evidence map›Paper›PMID 39779413›Full record

ReviewTrends in biochemical sciences2025

Stress responses induced by perturbation of the ubiquitin-proteasome system.

Mamta Rai, Liam C Hunt, Fabio Demontis

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mamta RaiDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Liam C HuntDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Biology, Rhodes College, 2000 North Pkwy, Memphis, TN 38112, USA.
Fabio DemontisDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: Fabio.Demontis@STJUDE.ORG.

Funding

REGULATION OF PROTEOSTASIS AND TAUOPATHY BY MALTOSE-INDUCED SIGNALINGR01AG075869 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Fabio Demontis · 2024 to 2026
$1.4M
NIA NIH HHS R01 AG075869
6 · The paper itself

Abstract

The ubiquitin-proteasome system is key for proteostasis and its disruption can induce several cellular adaptations. Here, we summarize the range of cellular responses that are induced by perturbation of distinct components of the ubiquitin-proteasome system, and how proteasome stress in a tissue can induce systemic responses in distant tissues.

Indexed as

Proteasome Endopeptidase ComplexStress, PhysiologicalUbiquitinAnimalsHumansProteostasisProteasome Endopeptidase ComplexUbiquitinE2 ubiquitin-conjugating enzymesingrained stress responseproteasomesystemic stress responseUBA1ubiquitination

Identifiers

PMID39779413
PMCPMC11890940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.