Evidence map›Paper›PMID 39779219›Full record

ArticleLife science alliance2025

COA5 has an essential role in the early stage of mitochondrial complex IV assembly.

Jia Xin Tang, Alfredo Cabrera-Orefice, Jana Meisterknecht, Lucie S Taylor, Geoffray Monteuuis, Maria Ekman Stensland, Adam Szczepanek, Karen Stals, James Davison, Langping He and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Advances in the molecular genetics of nuclear gene mutations causing pediatric mitochondrial cardiomyopathy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jia Xin TangMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Alfredo Cabrera-OreficeFunctional Proteomics Center, Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-2042-3794
Jana MeisterknechtFunctional Proteomics Center, Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
Lucie S TaylorMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Geoffray MonteuuisDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Maria Ekman StenslandDepartment of Immunology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Adam SzczepanekMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Karen StalsDepartment of Molecular Genetics, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
James DavisonDepartment of Paediatric Metabolic Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Langping HeNHS Highly Specialised Rare Mitochondrial Disorders Service, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK.
Sila HoptonNHS Highly Specialised Rare Mitochondrial Disorders Service, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK.
Tuula A NymanDepartment of Immunology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-8787-5886
Christopher B JacksonDepartment of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1035-6417
Angela PyleMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Monika WinterMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Ilka WittigFunctional Proteomics Center, Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany.
Robert W TaylorMitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK robert.taylor@ncl.ac.uk.ORCID 0000-0002-7768-8873

Funding

Medical Research Council (MRC) International Centre for Genomic Medicine in Neuromuscular Diseases MR/S005021/1UK NIHR Biomedical Research Centre in Age and Age-Related Diseases awardWellcome Trust
6 · The paper itself

Abstract

Pathogenic variants in cytochrome

Indexed as

Electron Transport Complex IVMitochondriaCRISPR-Cas SystemsFemaleFibroblastsHumansMaleMitochondrial DiseasesMitochondrial ProteinsMutation, MissensePedigreeElectron Transport Complex IVMitochondrial Proteins

Identifiers

PMID39779219
PMCPMC11711468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.