ArticleNature2025
An early precursor CD8
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- PD-1 regulates CD4Nature communications · 2026Article
- Exhausted CD8Nature immunology · 2026Article
- Adaptive resistance in cancer immunotherapy.Cellular & molecular immunology · 2026Review
- New insights into progenitor exhausted T cell populations.Nature reviews. Immunology · 2026Article
- Article
- T Cell Exhaustion as a Regulated Differentiation Programme.European journal of immunology · 2026Review
- Article
- PI3Kδ inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- HIV-driven virome dysbiosis unveils distinct virome features and inter-viral correlations in blood and respiratory niches.Communications biology · 2026Article
- CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.bioRxiv : the preprint server for biology · 2026Article
- Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity.The Journal of experimental medicine · 2026Article
- T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026Review
- Stem-like PD-1Journal for immunotherapy of cancer · 2026Article
- Article
- Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.Cell reports · 2026Article
- Tumor-targeted IL2 promotes specific CD8Journal of experimental & clinical cancer research : CR · 2026Article
- The ubiquitin ligase KLHL6 drives resistance to CD8Nature · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- CD4Translational lung cancer research · 2026Article
Corrections and comments
- Update of
Authors and funding
24 authors.
Daniel T McManus *Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0009-0003-1307-3380
Rajesh M Valanparambil *Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Christopher B MedinaEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7716-8504
Donald J McGuireEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Ewelina SobierajskaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Yinghong HuEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Daniel Y ChangDepartment of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8766-3768
Andreas WielandDepartment of Otolaryngology, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0001-9648-7922
Judong LeeEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7064-1079
Tahseen H NastiEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Masao HashimotoEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7120-1390
James L RossEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Nataliya ProkhnevskaThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maria A CardenasDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8566-9576
Amanda L GillEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-5827-8265
Elisa C ClarkDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4267-7215
Kathleen AbadieDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2021-7365
Arjun J KumarDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4354-5612
Jonathan KayeResearch Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Byron B Au-YeungDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University, Atlanta, GA, USA.
Hao Yuan KuehDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6272-6673
Haydn T KissickEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7624-5598
Rafi AhmedEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. rahmed@emory.edu.ORCID 0000-0002-9591-2621
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MT CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2MRegulation of CD4 T cell tolerance by the NR4A family of nuclear receptorsR01AI165706 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIE ZIKHERMAN · 2022 to 2026
$3.0MT Cell Memory to VirusesR01AI186330 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2024 to 2026
$1.9MInput encoding in T-cell receptor signalingR21EB027327 · NIBIB · UNIVERSITY OF WASHINGTON · PI KUEH, HAO YUAN · 2019 to 2021
$622kNIAID NIH HHS R01 AI030048NIAID NIH HHS R01 AI165706NIAID NIH HHS R01 AI186330NIBIB NIH HHS R21 EB027327NIH HHS P51 OD011132
Abstract
This study examines the origin and differentiation of stem-like CD8
Indexed as
CD8-Positive T-LymphocytesLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusPersistent InfectionAcute DiseaseAdoptive TransferAnimalsCell DifferentiationChronic DiseaseDisease Models, AnimalFemaleHepatocyte Nuclear Factor 1-alphaImmunologic MemoryMaleMiceMice, Inbred C57BLHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseProgrammed Cell Death 1 Receptor
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.