ArticleNature2025
Precursors of exhausted T cells are pre-emptively formed in acute infection.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63citing papers in PubMed
–field-weighted citation impact
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Who cites it
63 citing papers in PubMed.
- Chemo-metallo nanodrivers for spatiotemporally controlled in situ vaccination.Science advances · 2026Article
- Extracellular matrix reprogramming by the YAP/TAZ/TGF-β2 axis drives immune exclusion in cholangiocarcinoma models.The Journal of clinical investigation · 2026Article
- Exhausted CD8Nature immunology · 2026Article
- Decoding T cell exhaustion in the tumour microenvironment.Experimental & molecular medicine · 2026Review
- CAR-T and TIL therapies in solid tumors: barriers, clinical lessons, and convergent solutions.Cancer cell international · 2026Review
- Tumor-Associated Platelets Suppress T-cell Function and Promote Immune Evasion in TNBC via the P-selectin/P-selectin Glycoprotein Ligand 1 Pathway.Cancer research communications · 2026Article
- Adaptive resistance in cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism.PLoS pathogens · 2026Article
- New insights into progenitor exhausted T cell populations.Nature reviews. Immunology · 2026Article
- APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Spatially resolved T cell receptor tracking reveals γδT cell localization to tumor-rich regions in high-risk neuroblastoma: A Report from the Children's Oncology Group.medRxiv : the preprint server for health sciences · 2026Article
- Article
- ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories.Nature communications · 2026Article
- T Cell Exhaustion as a Regulated Differentiation Programme.European journal of immunology · 2026Review
- Amino Acids as Targets for Immunotherapy against Solid Tumors.Cell biochemistry and biophysics · 2026Review
- Multiregional profiling revealsScience advances · 2026Article
- Exhausted T cell phenotypes in disseminated coccidioidomycosis.JCI insight · 2026Article
- Article
- PI3Kδ inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- CKS1B is a tumor-intrinsic factor driving CD8Science advances · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Talyn Chu *Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Ming Wu *Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany. ming.wu@tum.de.ORCID 0000-0003-4515-6888
Barbara Hoellbacher *Institute of Computational Biology, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.ORCID 0000-0001-9848-7870
Gustavo P de Almeida *Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0002-2424-9818
Christine WurmserDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0003-0649-6206
Jacqueline BernerDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0002-9056-8745
Lara V DonhauserDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0002-7690-7501
Ann-Katrin GerullisDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0002-5445-7351
Siran LinDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
J Diego Cepeda-MayorgaDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Iman I KilbDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Lukas BongersDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Fabio ToppetaDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Philipp StroblDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Ben YoungbloodDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1261-9957
Anna M SchulzDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0001-6550-7206
Alfred ZippeliusCancer Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.ORCID 0000-0003-1933-8178
Percy A KnolleCenter for Infection Prevention (ZIP), School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID 0000-0003-2983-0414
Matthias HeinigInstitute of Computational Biology, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany. matthias.heinig@helmholtz-muenchen.de.ORCID 0000-0002-5612-1720
Carl-Philipp HacksteinDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany. carl-philipp.hackstein@tum.de.ORCID 0000-0002-0821-5204
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany. dietmar.zehn@tum.de.ORCID 0000-0003-1393-8527
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell exhaustion limits effector T cell function in chronic infection and tumours
Indexed as
Arenaviridae InfectionsLymphocytic choriomeningitis virusPrecursor Cells, T-LymphoidT-LymphocytesAcute DiseaseAnimalsCD8-Positive T-LymphocytesEpigenesis, GeneticFemaleHepatocyte Nuclear Factor 1-alphaImmunologic MemoryLigandsMaleMemory T CellsMiceMice, Inbred C57BLHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseLigandsPdcd1 protein, mouseProgrammed Cell Death 1 Receptor
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.