Evidence map›Paper›PMID 39778565›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2025

Profiling of Anti-Signal-Recognition Particle Antibodies and Clinical Characteristics in South Korean Patients With Immune-Mediated Necrotizing Myopathy.

Soo-Hyun Kim, Yunjung Choi, Eun Kyoung Oh, Ichizo Nishino, Shigeaki Suzuki, Bum Chun Suh, Ha Young Shin, Seung Woo Kim, Byeol-A Yoon, Seong-Il Oh and 9 more

Abstract read
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Soo-Hyun KimDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3161-9899
Yunjung ChoiDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1323-7421
Eun Kyoung OhDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4661-5209
Ichizo NishinoDepartment of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9452-112X
Shigeaki SuzukiDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4388-4574
Bum Chun SuhDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3947-5615
Ha Young ShinDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4408-8265
Seung Woo KimDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0235-1739
Byeol-A YoonDepartment of Neurology, Peripheral Neuropathy Research Center, College of Medicine, Dong-A University, Busan, Korea.ORCID https://orcid.org/0000-0002-4350-3551
Seong-Il OhDepartment of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8067-2135
Yoo Hwan KimDepartment of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.ORCID https://orcid.org/0000-0002-9532-5769
Hyunjin KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0264-4531
Young-Min LimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5074-812X
Seol-Hee BaekDepartment of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3656-1833
Je-Young ShinDepartment of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.ORCID https://orcid.org/0000-0001-5394-4839
Hung Youl SeokDepartment of Neurology, Keimyung University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0002-9938-5355
Seung-Ah LeeDepartment of Neurology, Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0727-638X
Young-Chul ChoiDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5525-6861
Hyung Jun ParkDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4165-8901

Funding

Yonsei University College of Medicine 6-2023-0215
6 · The paper itself

Abstract

background and purposeThis study evaluated the diagnostic utility of an anti-signal-recognition particle 54 (anti-SRP54) antibody-based enzyme-linked immunosorbent assay (ELISA) as well as the clinical, serological, and pathological characteristics of patients with SRP immune-mediated necrotizing myopathy (IMNM).

methodsWe evaluated 87 patients with idiopathic inflammatory myopathy and 107 healthy participants between January 2002 and December 2023. The sensitivity and specificity of the ELISA for anti-SRP54 antibodies were assessed, and the clinical profiles of patients with anti-SRP54 antibodies were determined.

resultsThe ELISA for anti-SRP54 antibodies had a sensitivity and specificity of 88% and 99%, respectively, along with a test-retest reliability of 0.92 (

conclusionsThis study has confirmed the reliability of the ELISA for anti-SRP54 antibodies and provided insights into the clinical, serological, and pathological characteristics of South Korean patients with anti-SRP IMNM.

Indexed as

anti-signal-recognition particle antibodyautoantibodiesenzyme-linked immunosorbent assayimmune-mediated necrotizing myopathymyositis

Identifiers

PMID39778565
PMCPMC11711272

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.