Evidence map›Paper›PMID 39778548›Full record

Observational studyNeuroepidemiology2025

Region of Birth Differences in Medication Adherence among Patients with Stroke or Transient Ischemic Attack.

Monique F Kilkenny, Lachlan L Dalli, Nadine E Andrew, David Ung, Joosup Kim, Vijaya Sundararajan, Dominique A Cadilhac, Amanda G Thrift, Mark R Nelson, Muideen T Olaiya

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neuroepidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monique F KilkennySchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia, monique.kilkenny@monash.edu.
Lachlan L DalliSchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Nadine E AndrewPeninsula Clinical School, School of Translational Medicine, Monash University, Frankston, Victoria, Australia.
David UngPeninsula Clinical School, School of Translational Medicine, Monash University, Frankston, Victoria, Australia.
Joosup KimSchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Vijaya SundararajanDepartment of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia.
Dominique A CadilhacSchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Amanda G ThriftSchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Mark R NelsonMenzies Institute for Medical Research, University of Tasmania, Hobart, Victoria, Australia.
Muideen T OlaiyaSchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCultural and language barriers may affect quality of care, such as adherence to medications. We examined whether adherence to prevention medications within the year after stroke/transient ischemic attack (TIA) differed by the region of birth.

methodsAn observational study of adults with stroke/TIA admitted to hospitals in the Australian Stroke Clinical Registry (Queensland, Victoria; 2012-2016; n = 45 hospitals). Data from the registry were linked with administrative data. Region of birth was categorized into 10 groups (Australia, Other Oceania, North-West Europe, Southern/Eastern Europe, North Africa/Middle East, South-East Asia, North-East Asia, Southern/Central Asia, Americas, Sub-Saharan Africa). Analysis was limited to those with a first-ever stroke/TIA who were dispensed an antihypertensive, lipid-lowering, or antithrombotic medication within 1-year post-discharge. Medication adherence was calculated based on the proportion of days covered until 1-year immediately post-discharge/death. Associations between region of birth and being adherent (PDC ≥80%) were determined using multivariable logistic regression (adjusted for age, sex, stroke type, ability to walk on admission, discharge destination, socioeconomic position, main language spoken, comorbidity score).

resultsAmong 24,236 eligible participants (median age 74 years, 44% female, 68% Australian-born), 54% were adherent to antihypertensive medications, 56% to lipid-lowering medications, and 49% to antithrombotic medications. Compared to Australian-born participants, those born in Other Oceania (4.0%) were less likely to be adherent to lipid-lowering medications (odds ratio [OR] 0.78, 95% CI: 0.67-0.90) and antithrombotic (OR 0.84, 95% CI: 0.72-0.97). Compared to Australian-born participants, those born in Southern and Central Asia (1.4%) were less likely to be adherent to lipid-lowering medications (OR: 0.76, 95% CI: 0.58-0.99) and antithrombotic (0.55, 95% CI: 0.40-0.76). No significant differences were found with other regions.

conclusionsDisparities by the region of birth were observed in medication adherence after stroke/TIA for participants born in Asia and Oceania. Targeted education to improve medication adherence, specific to the needs of these groups, is warranted.

Indexed as

Ischemic Attack, TransientMedication AdherenceStrokeAgedAged, 80 and overAntihypertensive AgentsAustraliaFemaleHumansMaleMiddle AgedRegistriesAntihypertensive AgentsCountry of birthMedication adherencePopulation registerStroke

Identifiers

PMID39778548
PMCPMC12688378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.