Evidence map›Paper›PMID 39778074›Full record

ArticleChemistryOpen2025

Substituent-Driven Anion-Binding Selectivity in Aliphatic Chain-Substituted 1,2-Phenylene Urea Macrocycles and Optimized Synthetic Methodology.

Kateřina Svobodová, Václav Eigner, Andrea Brancale, Petra Cuřínová, Michal Himl

Abstract read
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In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kateřina SvobodováDepartment of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague 6, 16628, Czech Republic.ORCID https://orcid.org/0009-0005-0385-9608
Václav EignerDepartment of Solid State Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague, 16628, Czech Republic.ORCID https://orcid.org/0000-0003-1014-3980
Andrea BrancaleDepartment of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague 6, 16628, Czech Republic.ORCID https://orcid.org/0000-0002-9728-3419
Petra CuřínováDepartment of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague 6, 16628, Czech Republic.ORCID https://orcid.org/0000-0001-8264-7032
Michal HimlDepartment of Organic Chemistry, University of Chemistry and Technology Prague, Technická 5, Prague 6, 16628, Czech Republic.ORCID https://orcid.org/0000-0002-9427-156X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,2-Phenylene tetraurea macrocycles recently attracted attention as self-assembled channel-making compounds with high selectivity to chlorides. Here, we report on the introduction of aliphatic chains in the periphery of the 1,2-phenylene tetraurea macrocycle, which led to deterioration in the ability of the macrocycle to form channels and to a reversal of anion binding preferences in favour of dihydrogen phosphate. In addition, we have developed a new method of synthesis of 1,2-phenylene tetraurea macrocycle, using a direct click of two diamino ureido derivatives by triphosgene in the presence of chloride template. This approach saves time and eliminates demanding isolation of the non-cyclic tetrameric intermediates.

Indexed as

Computational chemistryHost-guest systemsMacrocyclesTemplate synthesisUrea

Identifiers

PMID39778074
PMCPMC12957884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.