ArticleVeterinary medicine and science2025
Discovery of Novel Thiazolohydrazone Derivatives as an Alternative Option in the Treatment of Zoonotic Toxocara canis: In Vitro and In Silico Evaluation.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Hybridization of Naphthoquinones and Thiazoles: A Promising Strategy for Anticancer Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Thiazoles serve as pharmacophores in many molecules that exhibit significant biological activity. This study used in vitro assays and in silico methodologies to identify novel medication candidates for preclinical evaluation of visceral toxocariasis treatment. The objective was to assess the impact of 11 thiazolohydrazone derivative compounds on the larval eggs of Toxocara canis. In addition, the inhibitory effects of these compounds on IL-6 levels in THP-1 cells stimulated with larval eggs have been examined. Compounds indicating the most significant inhibitory effect on IL-6 and a suppressive effect on larval eggs have been included in molecular dynamics studies. The study revealed that, when evaluating all thiazolohydrazone derivatives together, Compounds 3g and 3h possessed the highest antiparasitic efficiency, encouraging further molecular dynamics investigations on these compounds. Consequently, it can be theorised that if the results from this study are corroborated by in vivo studies, new anti-nematodal medication candidates may be identified.
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Registered trials
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