Evidence map›Paper›PMID 39777789›Full record

ReviewEuropean journal of heart failure2025

Registries on transcatheter edge-to-edge repair in heart failure: Current evidence and future perspectives.

Gianluigi Savarese, Christian Basile, Marianna Adamo, Stefan D Anker, Antoni Bayes-Genis, Michael Böhm, Erwan Donal, Gerasimos S Filippatos, Francesco Maisano, Piotr Ponikowski and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gianluigi Savarese *Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-7732-0887
Christian Basile *Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-4680-3058
Marianna AdamoCardiology, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Stefan D AnkerDepartment of Cardiology and Berlin Institute of Health Center for Regenerative Therapies, German Center for Cardiovascular Research Partner Site Berlin, Charité Universitätsmedizin, Berlin, Germany.
Antoni Bayes-GenisHeart Institute, University Hospital Germans Trias i Pujol, CIBERCV, Badalona, Spain.
Michael BöhmInternal Medicine Clinic III, Cardiology, Angiology and Intensive Care Medicine, Saarland University, Homburg, Germany.
Erwan DonalUniversité de Rennes, CHU Rennes, Inserm, LTSI-UMR, Rennes, France.
Gerasimos S FilippatosDepartment of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Francesco MaisanoDepartment of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Piotr PonikowskiInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Giuseppe M C RosanoDepartment of Medical Sciences, IRCCS San Raffaele Roma, Rome, Italy.
Ralph Stephan von BardelebenDepartment of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Marco MetraCardiology, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Javed ButlerDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsSecondary mitral regurgitation (SMR) and tricuspid regurgitation (TR) are the most common valvular heart diseases in patients with heart failure (HF). Transcatheter edge-to-edge repair (TEER) devices designed for treating MR and TR have been successfully tested in randomized controlled trials, but methodological issues have often challenged their interpretation. This manuscript aimed to provide an overview of TEER registries on SMR and TR in HF, highlighting their key features, describing clinical characteristics and outcomes of patients receiving these devices, and exploring the available data limitations. METHODS AND

resultsPubMed, Web of Science, and EMBASE were searched for registries reporting on TEER in SMR or TR. Registries were excluded if single-centre and with <100 patients. Twenty-six registries (46% prospective, 12% ongoing), including a total cohort of 18 925 patients, were retrieved for TEER in SMR, and six registries (50% retrospective, 33% ongoing) reported on the use of TEER for TR in a total cohort of 1412 patients. Limited geographical representativity outside North America and Europe, high number of missing values, and inconsistency in data reporting were the main existing evidence limitations.

conclusionRegistries on TEER represent a key data source in a setting where it is difficult to conduct randomized controlled trials. However, limitations in design, patient characterization, and outcomes reporting restrain their use. A novel conceptual framework for future prospective TEER registries, as proposed in this document, might inform current practice, address relevant clinical questions and future trial design.

Indexed as

Cardiac CatheterizationHeart FailureHeart Valve Prosthesis ImplantationMitral Valve InsufficiencyRegistriesTricuspid Valve InsufficiencyHumansHeart failureMitral regurgitationRegistriesTranscatheter edge‐to‐edge repairTricuspid regurgitationValvular heart disease

Identifiers

PMID39777789
PMCPMC12482848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.