ArticleJournal of materials science. Materials in medicine2025
Histological and histomorphometric evaluation of natural bovine bone substitute with hyaluronate in socket preservation-a report of three cases.
Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study.Acta stomatologica Croatica · 2026Article
- Alveolar Ridge Preservation Revisited: A Multimodal Evaluation of Bone Preservation and Regeneration-Preliminary Findings from a Randomized Controlled Clinical Trial.Bioengineering (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
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Abstract
Tooth extraction is physiologically followed by resorption of alveolar bone. Surgical method which aims to minimise this reduction in alveolar bone with a goal to provide enough bone volume for dental implant insertion is called socket preservation. The purpose of this article was to asses clinical, histomorphometric and histological results of socket preservation conducted with natural bovine bone substitute with hyaluronate. Three patients with one or more hopeless teeth in posterior region planned for extraction and implant placement were included in these case reports. After atraumatic extractions, empty sockets were filled with the bovine xenograft with hyaluronate, and then covered with collagen sponge. After 4-7.5 months the samples for biopsy were taken and then implants were inserted. The augmented sites healed uneventfully and without any complications. The histological specimens demonstrated new bone formation and osteoclastic activity around the biomaterial, as well as blood vessels in soft tissue. Histomorphometrically, formation of new bone averaged 24.8% ± 4.7% (mean ± standard deviation) in bone biopsies taken from the center of the augmented site, while the residual biomaterial averaged 52.7% ± 4.9% and the soft tissue averaged 22.6% ± 4%. In conclusion, the natural bovine bone substitute with hyaluronate demonstrated excellent osteoconductive potential for bone regeneration.
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