ReviewRheumatology international2025
Unveiling the enigma: a case-based review of scleromyxedema.
Review in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
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Abstract
Scleromyxedema is a rare chronic fibromucinous disorder characterized by a generalized papular and sclerodermoid eruption. Despite its clinical significance, no definitive therapeutic guidelines exist for scleromyxedema, making management challenging. Herein, we present a case of a 76-year-old female patient referred for evaluation of systemic sclerosis, presenting with distinctive cutaneous manifestations and neurological symptoms. Investigations revealed monoclonal gammopathy (IgG Lambda subtype) and antinuclear antibodies, supporting a diagnosis of scleromyxedema. A multidisciplinary approach with intravenous immunoglobulin (IVIG) therapy resulted in significant improvement in neurological and cutaneous symptoms. This case underscores the challenges of diagnosing and managing scleromyxedema and highlights IVIG as a potential therapeutic option in the absence of standardized guidelines.
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39777523What OpenQuestion holds
Registered trials
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