Evidence map›Paper›PMID 39777514›Full record

ArticleThe Journal of infectious diseases2025

CCL17 Influences Borrelia burgdorferi Infection in the Heart.

Xiaotian Tang, Qian Yu, Yingjun Cui, Thomas M Hart, Freddie Rivas-Giorgi, Keith Calloway, Amrita Ray Mohapatra, Erol Fikrig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaotian TangZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Qian YuSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-2396-2128
Yingjun CuiSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Thomas M HartSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Freddie Rivas-GiorgiMolecular Biochemistry and Biophysics Program, Yale College, New Haven, Connecticut, USA.
Keith CallowaySection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Amrita Ray MohapatraSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
Howard Hughes Medical InstituteNIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI126033NIDDK NIH HHS P30 DK034989NIH HHS AI126033NIH HHS AI138949Steven and Alexandra Cohen Foundation
6 · The paper itself

Abstract

Lyme disease, caused by Borrelia burgdorferi, is transmitted to humans by Ixodes ticks. CCL17 is a potent chemokine that plays important roles in diverse illnesses, including autoimmune and infectious diseases. CCL17 knockout mice, infected with B. burgdorferi, had a reduced pathogen load in the heart compared to control animals. Mice lacking CCL17 also showed signs of immune alteration upon B. burgdorferi infection, including diverse serum levels of proinflammatory cytokines and less monocytes and macrophages infiltration. CCL17 also interacts directly with B. burgdorferi, the first demonstration that this chemokine has an affinity for a vector-borne pathogen.

Indexed as

Borrelia burgdorferiChemokine CCL17HeartLyme DiseaseAnimalsCytokinesHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutMonocytesChemokine CCL17CytokinesBorrelia burgdorferiCCL17heartinfectionLyme disease

Identifiers

PMID39777514
PMCPMC12308671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.