ArticleThe Journal of experimental medicine2025
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis.
Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- On or within: spatial determinants of antigen handling in the nasal turbinates.Current opinion in immunology · 2026Review
- Lymphatic Endothelial Cells in Health and Disease.MedComm · 2026Review
- Article
- Article
- Amyloidosis of bridging veins is a pathologic feature of Alzheimer's disease.The Journal of experimental medicine · 2026Article
- The cribriform plate: A dynamic central nervous system-immune hub.The Journal of experimental medicine · 2026Review
- Possible Impact of Lymphatic Drainage on Brain Injury After Aneurysmal Subarachnoid Hemorrhage.International journal of molecular sciences · 2026Review
- Mechanical Ventilation Suppresses Glymphatic Function in Parallel with Delirium-Like Symptoms in Mice.bioRxiv : the preprint server for biology · 2025Article
- Review
- Glymphatic and meningeal lymphatic dysfunction in Alzheimer's disease: Mechanisms and therapeutic perspectives.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Redefining CNS immune privilege.Nature reviews. Immunology · 2025Review
- Cerebrospinal fluid draining lymphatics in health and disease: advances and controversies.Nature cardiovascular research · 2025Review
- Article
- CSF transport at the brain-meningeal border: effects on neurological health and disease.The Lancet. Neurology · 2025Review
- Age-related meningeal extracellular matrix remodeling compromises CNS lymphatic function.Journal of neuroinflammation · 2025Article
- Skull-meninges-brain connectivity and extra-axial brain tumours.Brain communications · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to neuroinflammatory and neurodegenerative disorders, but our understanding of the lymphatic contribution to CNS fluid autoregulation remains limited. Here, we studied forces that drive the outflow of the cerebrospinal fluid (CSF) into the deep and superficial cervical lymph nodes (dcLN and scLN) and tested how the blockade of lymphatic networks affects CNS fluid homeostasis. Outflow to the dcLN occurred spontaneously in the absence of lymphatic pumping and was coupled to intracranial pressure (ICP), whereas scLN drainage was driven by pumping. Impaired dcLN drainage led to elevated CSF outflow resistance and delayed CSF-to-blood efflux despite the recruitment of the nasal-to-scLN pathway. Fluid regulation was better compensated after scLN obstruction. The dcLN pathway exhibited steady, consistent drainage across conditions, while the nasal-to-scLN pathway was dynamically activated to mitigate perturbances. These findings highlight the complex physiology of CSF homeostasis and lay the groundwork for future studies aimed at assessing and modulating CNS lymphatic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.