ArticleHealth science reports2025
Microgravity and Cardiovascular Health in Astronauts: A Narrative Review.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Simulated microgravity induces a NOX-sensitive oxidative response that is attenuated by resveratrol in human endothelial cells.Scientific reports · 2026Article
- The effect of spaceflight and simulated microgravity exposure on thermoregulation in humans: a systematic review.NPJ microgravity · 2026Article
- Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.Military Medical Research · 2026Article
- Regenerative Medicine in Space: Advancing Bone Repair with Adipose-Derived Stem Cells and Bone-on-Chip Technology.Methods in molecular biology (Clifton, N.J.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Space exploration has become a major interest for scientific and medical research. With increasing duration and frequency of manned space missions, it is crucial to understand the impact of microgravity on the cardiovascular health of astronauts. We focus on this relationship by reviewing literature that explores how microgravity affects several hemodynamic parameters and cardiovascular biomarkers. Methods: We conducted a search updated to November 2024 across several databases, including PubMed, Cochrane Library, ESA, NASA and DLR, using relevant MeSH terms and selection criteria. Results: The 22 selected articles detail how microgravity impacts the cardiovascular system and its adaptations. We identify some clear patterns, such as loss of ventricular mass and increased QT intervals (corrected for heart rate) indicating increased risk of arrhythmias. Our analysis confirms that head-down tilt is an accurate analog of microgravity. Conclusions: While a direct link between microgravity and cardiovascular disease, such as coronary heart disease and myocardial infarction, remains elusive, the documented physiological changes pose a potential threat to the astronauts' health. We suggest that future research focus on long-term effects, particularly on female subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.