Evidence map›Paper›PMID 39777242›Full record

ArticleWorld journal of gastroenterology2025

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy.

Xin Zhou, Dan Ma, Yi-Xiang He, Jing Jin, Hong-Lian Wang, Yun-Feng Wang, Fan Yang, Jian-Qin Liu, Jie Chen, Zhi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Therapeutic potential ofPharmaceutical biology · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin ZhouDepartment of Spleen and Stomach Diseases, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Dan MaDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 20082, China.
Yi-Xiang HeDepartment of Spleen and Stomach Diseases, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Jing JinDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 20082, China.
Hong-Lian WangResearch Center of Integrated Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Yun-Feng WangDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 20082, China.
Fan YangDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 20082, China.
Jian-Qin LiuThe Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Jie ChenDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 20082, China.
Zhi LiDepartment of Spleen and Stomach Diseases, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal stricture ranks among the most significant complications following endoscopic submucosal dissection (ESD). Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.

aimTo examine the effectiveness and underlying mechanism of Kangfuxin solution (KFX) in mitigating excessive fibrotic repair of the esophagus post-ESD.

methodsPigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD. Endoscopic examinations occurred on days 7 and 21 post-ESD.

resultsCompared to the Control group, the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis, lower weight loss rates, and improved food tolerance 21 d after ESD. After treatment, Masson staining revealed thinner and less dense collagen fibers in the submucosal layer. Additionally, the expression of fibrotic effector molecules was notably inhibited. Mechanistically, KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1, Smad2/3, and p-Smad2/3.

conclusionKFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures, potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

Indexed as

Endoscopic Mucosal ResectionEsophageal StenosisFibrosisAnimalsBiological ProductsCells, CulturedDisease Models, AnimalEsophageal MucosaEsophagusFibroblastsHumansMateria MedicaPostoperative ComplicationsSignal TransductionSmad ProteinsSwineBiological ProductskangfuxinMateria MedicaSmad ProteinsTransforming Growth Factor beta1Endoscopic submucosal dissectionEsophagus strictureFibrosisKangfuxin solutionNatural component

Identifiers

PMID39777242
PMCPMC11684190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.