Evidence map›Paper›PMID 39777210›Full record

ArticleBiomedical reports2025

Bioactive potency of extracts from

Moath Alqaraleh, Khaled M Khleifat, Ali Al-Samydai, Belal O Al-Najjar, Fadi G Saqallah, Yaseen T Al Qaisi, Ahmad Z Alsarayreh, Dana A Alqudah, Abdulfattah S Fararjeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Moath AlqaralehDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt 19117, Jordan.
Khaled M KhleifatDepartment of Medical Laboratory Sciences, Faculty of Science, Mutah University, Al-Karak 61710, Jordan.
Ali Al-SamydaiDepartment of Pharmaceutical and Pharmaceutical Technology, Faculty of Pharmacy, Pharmacological and Diagnostic Research Center, Al-Ahliyya Amman University, Amman 11814, Jordan.
Belal O Al-NajjarDepartment of Pharmaceutical and Pharmaceutical Technology, Faculty of Pharmacy, Pharmacological and Diagnostic Research Center, Al-Ahliyya Amman University, Amman 11814, Jordan.
Fadi G SaqallahDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Yaseen T Al QaisiDepartment of Biological Sciences, Faculty of Science, Mutah University, Al-Karak 61710, Jordan.
Ahmad Z AlsarayrehDepartment of Biological Sciences, Faculty of Science, Mutah University, Al-Karak 61710, Jordan.
Dana A AlqudahDepartment of Pharmaceutics and Technology, Cell Therapy Center, The University of Jordan, Amman 11942, Jordan.
Abdulfattah S FararjehDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt 19117, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver nanoparticles (AgNPs) are spherical particles with a number of specific and unique physical (such as surface plasmon resonance, high electrical conductivity and thermal stability) as well as chemical (including antimicrobial activity, catalytic efficiency and the ability to form conjugates with biomolecules) properties. These properties allow AgNPs to exhibit desired interactions with the biological system and make them prospective candidates for use in antibacterial and anticancer activities. AgNPs have a quenching capacity, which produces reactive oxygen species and disrupts cellular processes (such as reducing the function of the mitochondria, damaging the cell membrane, inhibiting DNA replication and altering protein synthesis). In addition, sponge extracts contain biologically active substances with therapeutic effects. Therefore, the concurrent use of these agents may present a potential for the development of novel antitumor and antimicrobial drugs. The present study investigated the cytotoxic effects of AgNPs combined with the extracts from sponge species,

Indexed as

AgNPsAmphimedon chlorosantibacterial activityEGFR inhibitionStylissa carteriTrkA inhibition

Identifiers

PMID39777210
PMCPMC11704841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.