Evidence map›Paper›PMID 39776911›Full record

ArticleFrontiers in immunology2024

Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8

Ziwei Wang, Ruiqi Li, Weijia Fu, Hui Cheng, Yan Zhang, Gusheng Tang, Jianmin Yang, Jianmin Wang, Xiong Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziwei Wang *Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Ruiqi Li *Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Weijia Fu *Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Hui ChengDepartment of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Yan ZhangDepartment of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Gusheng TangDepartment of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Jianmin YangDepartment of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Jianmin WangDepartment of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Xiong NiDepartment of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge. Materials and methods: Here, we used a representative cGVHD model with the donor C57BL/6 to recipient BALB/c combination. Post-HCT, mice were treated with IgG or anti-CD4 monoclonal antibody. The severity of cGVHD was assessed by evaluating symptoms of cGVHD and histopathology examination (H&E) of target organs. Thymus gland damage and defects of the negative selection were assessed by analyzing the CD4 Results: Donor CD8 Conclusion: Our results indicate that anti-CD4 mAb therapy early post-HCT allows thymus recovery by inducing the immune tolerance of thymus infiltrated CD8

Indexed as

Antibodies, MonoclonalCD8-Positive T-LymphocytesGraft vs Host DiseaseHematopoietic Stem Cell TransplantationImmune ToleranceMice, Inbred BALB CThymus GlandAnimalsCD4 AntigensCD4-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalMiceMice, Inbred C57BLTransplantation, HomologousAntibodies, MonoclonalCD4 Antigensanti-CD4 monoclonal antibodyCD4 + T cellschronic graft-versus-host diseaseimmune tolerancethymic recovery

Identifiers

PMID39776911
PMCPMC11703850

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.