Evidence map›Paper›PMID 39776801›Full record

ArticleTheranostics2025

Monitoring of cancer ferroptosis with [

Abraham Moses, Rim Malek, Mustafa Tansel Kendirli, Pierre Cheung, Madeleine Landry, Marco Herrera-Barrera, Abbas Khojasteh, Monica Granucci, Syed A Bukhari, Jody E Hooper and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abraham MosesDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA, 94305, USA.
Rim MalekDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA, 94305, USA.
Mustafa Tansel KendirliDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Pierre CheungDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA, 94305, USA.
Madeleine LandryDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA, 94305, USA.
Marco Herrera-BarreraStanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Abbas KhojastehDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Monica GranucciDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Syed A BukhariDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Jody E HooperDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Melanie Hayden-GephartDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA, 94305, USA.
Lawrence D RechtDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Corinne BeinatDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA, 94305, USA.

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
TOOLKIT CoreU54CA261717 · NCI · STANFORD UNIVERSITY · PI Melanie Hayden Gephart · 2021 to 2026
$8.9M
Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
Characterizing the Regulation of FerroptosisR01GM122923 · NIGMS · STANFORD UNIVERSITY · PI Scott Dixon · 2017 to 2026
$3.4M
Novel applications and translation of [18F]hGTS13, a system xc- specific radiopharmaceuticalR01CA291644 · NCI · STANFORD UNIVERSITY · PI Corinne Beinat · 2024 to 2026
$2.0M
(PQ1) Identifying and targeting human glioblastoma migrating in the peritumoral nicheR01CA216054 · NCI · STANFORD UNIVERSITY · PI HAYDEN GEPHART, MELANIE · 2017 to 2021
$1.7M
NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA216054NCI NIH HHS R01 CA291644NCI NIH HHS T32 CA118681NCI NIH HHS U54 CA261717NIGMS NIH HHS R01 GM122923
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, characterized by resistance to conventional therapies and poor survival. Ferroptosis, a form of regulated cell death driven by lipid peroxidation, has recently emerged as a promising therapeutic target for GBM treatment. However, there are currently no non-invasive imaging techniques to monitor the engagement of pro-ferroptotic compounds with their respective targets, or to monitor the efficacy of ferroptosis-based therapies. System xc-, an important player in cellular redox homeostasis, plays a critical role in ferroptosis by mediating the exchange of cystine for glutamate, thus regulating the availability of cysteine, a crucial precursor for glutathione synthesis, and influencing the cellular antioxidant defense system. We have recently reported the development and validation of [

Indexed as

Brain NeoplasmsFerroptosisFluorine RadioisotopesGlioblastomaRadiopharmaceuticalsAmino Acid Transport System y+AnimalsCell Line, TumorHumansMaleRatsRats, Sprague-DawleyAmino Acid Transport System y+Fluorine RadioisotopesRadiopharmaceuticals[18F]hGTS13ferroptosisPET imagingsystem xc-

Identifiers

PMID39776801
PMCPMC11700874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.