Evidence map›Paper›PMID 39776769›Full record

ArticleNeurology. Clinical practice2025

Industry Payments and Branded Glatiramer Acetate Prescribing in the US Medicare Program.

Daniel M Hartung, Sheila Markwardt, Dennis Bourdette

Abstract read
In one paragraph

Article in Neurology. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel M HartungCollege of Pharmacy, Oregon State University, Portland, OR.ORCID https://orcid.org/0000-0002-0685-773X
Sheila MarkwardtBiostatistics and Design Program, Oregon Health & Science University, Portland, OR; and.ORCID https://orcid.org/0000-0002-4929-4359
Dennis BourdetteDepartment of Neurology; Oregon Health & Science University; Portland, Oregon.ORCID https://orcid.org/0000-0002-1312-8615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Generic formulations of glatiramer acetate have been available since 2015 yet remain underprescribed relative to the branded product. We sought to characterize the association between branded glatiramer prescribing in the Medicare program and financial payments from the manufacturer (Teva Pharmaceuticals). Methods: Using publicly available Medicare Part D and Open Payments data from the Centers for Medicare and Medicaid Services, we evaluated overall utilization from 2012 to 2021 and compared the prevalence, frequency, and magnitude of financial payments made in 2019 to neurologists who prescribed branded and generic versions of glatiramer in 2020. A multivariable logistic regression model assessed the association between receiving payments from the manufacturer and branded glatiramer prescribing while adjusting for neurologist demographic and practice characteristics. Results: In 2021, 52% of glatiramer prescriptions were for a branded formulation. Of 2,886 neurologists who prescribed glatiramer in 2020, 1,323 (46%) only prescribed branded, 364 (22%) only prescribed generic, and 929 (32%) prescribed both branded and generic versions of glatiramer. Of branded glatiramer prescribers, 53% (702 of 1,323) received a payment from the manufacturer compared with 39% (247 of 634) of generic-only prescribers ( Discussion: Although branded drugs often rapidly lose market share with generic competition, branded glatiramer prescribing may persist because of ongoing financial relationships between neurologists and the manufacturer.

Identifiers

PMID39776769
PMCPMC11702905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.